Botulinum neurotoxins: biology, pharmacology, and toxicology
The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel
BoNTs are being discovered owing to next generation sequencing, but their biologic and …
BoNTs are being discovered owing to next generation sequencing, but their biologic and …
Botulinum neurotoxins: genetic, structural and mechanistic insights
Botulinum neurotoxins (BoNTs) are produced by anaerobic bacteria of the genus
Clostridium and cause a persistent paralysis of peripheral nerve terminals, which is known …
Clostridium and cause a persistent paralysis of peripheral nerve terminals, which is known …
Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection
The recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is
responsible for a worldwide pandemic. Given the global health emergency, drug …
responsible for a worldwide pandemic. Given the global health emergency, drug …
Botulinum and tetanus neurotoxins
Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins
known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as …
known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as …
Synergistic antiviral effect of hydroxychloroquine and azithromycin in combination against SARS-CoV-2: What molecular dynamics studies of virus-host interactions …
The emergence of SARS-coronavirus-2 (SARS-CoV-2) has led to a global pandemic
disease referred to as coronavirus disease 19 (COVID-19). Hydroxychloroquine (CLQ …
disease referred to as coronavirus disease 19 (COVID-19). Hydroxychloroquine (CLQ …
Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2
Abstract Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and
paradoxically also a promising therapeutic agent. Here we determined the co-crystal …
paradoxically also a promising therapeutic agent. Here we determined the co-crystal …
Identification of a novel botulinum neurotoxin gene cluster in Enterococcus
J Brunt, AT Carter, SC Stringer, MW Peck - FEBS letters, 2018 - Wiley Online Library
The deadly neurotoxins of Clostridium botulinum (BoNTs) comprise eight serotypes (A–G;
X). The neurotoxin gene cluster encoding BoNT and its accessory proteins includes an …
X). The neurotoxin gene cluster encoding BoNT and its accessory proteins includes an …
The long journey of botulinum neurotoxins into the synapse
A Rummel - Toxicon, 2015 - Elsevier
Botulinum neurotoxins (BoNT) cause the disease botulism, a flaccid paralysis of the muscle.
They are also very effective, widely used medicines applied locally in sub-nanogram …
They are also very effective, widely used medicines applied locally in sub-nanogram …
The structure of the tetanus toxin reveals pH‐mediated domain dynamics
G Masuyer, J Conrad, P Stenmark - EMBO reports, 2017 - embopress.org
The tetanus neurotoxin (Te NT) is a highly potent toxin produced by Clostridium tetani that
inhibits neurotransmission of inhibitory interneurons, causing spastic paralysis in the tetanus …
inhibits neurotransmission of inhibitory interneurons, causing spastic paralysis in the tetanus …
Ganglioside binding domains in proteins: Physiological and pathological mechanisms
Gangliosides are anionic lipids that form condensed membrane clusters (lipid rafts) and
exert major regulatory functions on a wide range of proteins. In this review, we propose a …
exert major regulatory functions on a wide range of proteins. In this review, we propose a …