Lipids are abundant and play essential roles in human health and disease. The main
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …

B cells develop from hematopoietic precursor cells in an ordered maturation and selection
process. Extensive studies with many different mouse mutants provided fundamental …

Extensive experimental evidence shows that platelets support tumour metastasis. The
activation of platelets and the coagulation system have a crucial role in the progression of …

Abstract Sphingosine-1-phosphate (S1P), a potent signalling lipid secreted by red blood
cells and platelets,, plays numerous biologically significant roles,,,. However, the identity of …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Background: Bleeding is the most frequent cause of preventable death after severe injury.
Coagulopathy associated with severe injury complicates the control of bleeding and is …

Substances released by platelets during blood clotting are essential participants in events
that link hemostasis and angiogenesis and ensure adequate wound healing and tissue …

Obesity predisposes individuals to the development of insulin resistance in skeletal muscle
and the liver, and researchers have recently proposed two mechanisms by which excess …

▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …

The kidney is comprised of heterogeneous cell populations that function together to perform
a number of tightly controlled, complex and interdependent processes. Renal endothelial …