Manipulating the destiny of wild populations using CRISPR

R Raban, JM Marshall, BA Hay… - Annual review of …, 2023 - annualreviews.org
Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

Leveraging eco-evolutionary models for gene drive risk assessment

MA Combs, AJ Golnar, JM Overcash, AL Lloyd… - Trends in Genetics, 2023 - cell.com
Engineered gene drives create potential for both widespread benefits and irreversible harms
to ecosystems. CRISPR-based systems of allelic conversion have rapidly accelerated gene …

Eliminating malaria vectors with precision-guided sterile males

RA Apte, AL Smidler, JJ Pai, ML Chow, S Chen… - Proceedings of the …, 2024 - pnas.org
Controlling the principal African malaria vector, the mosquito Anopheles gambiae, is
considered essential to curtail malaria transmission. However, existing vector control …

[HTML][HTML] Eliminating malaria vectors with precision guided sterile males

AL Smidler, RA Apte, JJ Pai, ML Chow, S Chen… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Controlling the principal African malaria vector, the mosquito Anopheles gambiae, is
considered essential to curtail malaria transmission. However existing vector control …

Improving risk governance strategies via learning: a comparative analysis of solar radiation modification and gene drives

K Grieger, JB Wiener, J Kuzma - Environment Systems and Decisions, 2024 - Springer
Stratospheric aerosol injection (SAI) and gene drive organisms (GDOs) have been proposed
as technological responses to complex entrenched environmental challenges. They also …

A framework for identifying fertility gene targets for mammalian pest control

AC Clark, R Edison, K Esvelt, S Kamau… - Molecular ecology …, 2024 - Wiley Online Library
Fertility‐targeted gene drives have been proposed as an ethical genetic approach for
managing wild populations of vertebrate pests for public health and conservation benefit …

[HTML][HTML] Taking stock: Is gene drive research delivering on its principles?

AJ Roberts, K Hackett, I Coche… - Gates Open …, 2024 - gatesopenresearch.org
Gene drive technology has been recognized for its potential to provide durable and cost-
effective solutions for previously intractable problems in public health, conservation, and …

To CRISPR or Not to CRISPR? Ethical Considerations in Gene-Editing Insects

B Parent, M Barrett - American Entomologist, 2024 - academic.oup.com
modified corn has helped feed the world (Hernandes-Lopes et al.). Genetically modified
mosquitoes could help eliminate devastating diseases like malaria (Hammond and Galizi) …