Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

Cell migration affects all morphogenetic processes and contributes to numerous diseases,
including cancer and cardiovascular disease. For most cells in most environments …

Blood platelets are critical for hemostasis and thrombosis and play diverse roles during
immune responses. Despite these versatile tasks in mammalian biology, their skills on a …

Non-muscle myosin II (NM II) is an actin-binding protein that has actin cross-linking and
contractile properties and is regulated by the phosphorylation of its light and heavy chains …

Growing evidence suggests that the physical properties of the cellular microenvironment
influence cell migration. However, it is not currently understood how active physical …

Keratinocytes, the predominant cell type of the epidermis, migrate to reinstate the epithelial
barrier during wound healing. Mechanical cues are known to regulate keratinocyte re …

Cell shape changes underlie a large set of biological processes ranging from cell division to
cell motility. Stereotyped patterns of cell shape changes also determine tissue remodeling …

Crawling locomotion of eukaryotic cells is achieved by a process dependent on the actin
cytoskeleton: protrusion of the leading edge requires assembly of a network of actin …

Keratocytes are fast-moving cells in which adhesion dynamics are tightly coupled to the
actin polymerization motor that drives migration, resulting in highly coordinated cell …

Biological tissues are composed of various cell types working cooperatively to perform their
respective function within organs and the whole body. During development, embryogenesis …