Acute myeloid leukemia (AML) remains the most lethal of leukemias and a small population
of cells called leukemic stem cells (LSCs) has been associated with disease relapses. Some …

Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and
children, yet significant numbers of patients relapse and die of disease. In this study, we …

Targeting kinase activity is considered to be an attractive therapeutic strategy to overcome
acute myeloid leukemia (AML) since aberrant activation of the kinase pathway plays a …

Key molecular drivers that underlie transformation of colonic epithelium into colorectal
adenocarcinoma (CRC) are well described. However, the mechanisms through which …

In addition to apoptosis resistance and cell proliferation capacities, the undifferentiated state
also characterizes most cancer cells, especially leukemia cells. Cell differentiation is a …

The role of histone deacetylase inhibitors in the treatment of acute myeloid leukemia (AML)
is not well characterized. The current study evaluated the safety and efficacy of panobinostat …

In approximately 15% of patients with acute myeloid leukemia (AML), total and
phosphorylated EGFR proteins have been reported to be increased compared to healthy …

Background/Aim: A great proportion of patients with rectal cancer initially present with locally
advanced disease and can potentially benefit from neoadjuvant concurrent …

Comprehensive genomic profiling examinations (CGPs) have recently been developed, and
a variety of tumor-agnostic mutations have been detected, leading to the development of …

Differentiation therapy using all-trans retinoic acid (ATRA) is well established for the
treatment of acute promyelocytic leukemia (APL). Several attempts have been made to treat …