Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy
caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic …

Vaccine-induced immune thrombotic thrombocytopaenia (VITT) is a rare adverse effect of
COVID-19 adenoviral vector vaccines,–. VITT resembles heparin-induced …

Key Clinical Points Heparin-Induced Thrombocytopenia Heparin-induced thrombocytopenia
(HIT) is characterized by a decrease in the platelet count of more than 50% from the highest …

Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Although the rate of acute severe adverse cutaneous reactions to medications is low, these
reactions can affect anyone who takes medications and can result in death or disability1 …

Background Heparin-induced thrombocytopenia, defined by the presence of heparin-
dependent IgG antibodies, typically occurs five or more days after the start of heparin …

Introduction: Heparin-induced thrombocytopenia (HIT) is known for its strong association
with thrombosis and distinct pathogenesis involving anti-PF4/polyanion antibodies that …

Abbreviations: ACT activated clotting time; APTT activated partial thromboplastin time; AT
antithrombin; AT-III antithrombin III; CI confidence interval; DVT deep vein thrombosis; GP …

Background Thrombocytopenia and thrombosis are prominent in coronavirus disease 2019
(COVID‐19), particularly among critically ill patients; however, the mechanism is unclear …