Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer's disease

G Verdile, KN Keane, VF Cruzat, S Medic… - Mediators of …, 2015 - Wiley Online Library
Type 2 diabetes (T2DM), Alzheimer's disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …

The role of type 2 diabetes in neurodegeneration

G Verdile, SJ Fuller, RN Martins - Neurobiology of disease, 2015 - Elsevier
A growing body of evidence links type-2 diabetes (T2D) with dementia and
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …

Prevalence and risk of progression of preclinical Alzheimer's disease stages: a systematic review and meta-analysis

L Parnetti, E Chipi, N Salvadori, K D'Andrea… - Alzheimer's research & …, 2019 - Springer
Background Alzheimer's disease (AD) pathology begins several years before the clinical
onset. The long preclinical phase is composed of three stages according to the …

2014 Update of the Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception

MW Weiner, DP Veitch, PS Aisen, LA Beckett… - Alzheimer's & …, 2015 - Elsevier
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) is an ongoing,
longitudinal, multicenter study designed to develop clinical, imaging, genetic, and …

Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease

E Guzmán-Vélez, I Diez… - Proceedings of the …, 2022 - National Acad Sciences
The human brain is composed of functional networks that have a modular topology, where
brain regions are organized into communities that form internally dense (segregated) and …

Early versus late MCI: Improved MCI staging using a neuropsychological approach

EC Edmonds, CR McDonald, A Marshall… - Alzheimer's & …, 2019 - Elsevier
Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) separates
“early” and “late” mild cognitive impairment (MCI) based on a single memory test. We …

Florbetapir F 18 amyloid PET and 36-month cognitive decline: a prospective multicenter study

PM Doraiswamy, RA Sperling, K Johnson… - Molecular …, 2014 - nature.com
This study was designed to evaluate whether subjects with amyloid beta (Aβ) pathology,
detected using florbetapir positron emission tomorgraphy (PET), demonstrated greater …

The role of apolipoprotein E (APOE) genotype in early mild cognitive impairment (E-MCI)

SL Risacher, S Kim, L Shen, K Nho… - Frontiers in aging …, 2013 - frontiersin.org
Objective: Our goal was to evaluate the association of APOE with amyloid deposition,
cerebrospinal fluid levels (CSF) of Aβ, tau, and p-tau, brain atrophy, cognition and cognitive …

Cognitive correlates of basal forebrain atrophy and associated cortical hypometabolism in mild cognitive impairment

MJ Grothe, H Heinsen, E Amaro Jr, LT Grinberg… - Cerebral …, 2016 - academic.oup.com
Degeneration of basal forebrain (BF) cholinergic nuclei is associated with cognitive decline,
and this effect is believed to be mediated by neuronal dysfunction in the denervated cortical …

Multi-modal feature selection with feature correlation and feature structure fusion for MCI and AD classification

Z Jiao, S Chen, H Shi, J Xu - Brain Sciences, 2022 - mdpi.com
Feature selection for multiple types of data has been widely applied in mild cognitive
impairment (MCI) and Alzheimer's disease (AD) classification research. Combining multi …