Interferons (IFNs) constitute the first line of defense against microbial infections particularly
against viruses. They provide antiviral properties to cells by inducing the expression of …

Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19,
utilizes angiotensin-converting enzyme 2 (ACE2) for entry into target cells. ACE2 has been …

Interferons induced early after SARS-CoV-2 infection are crucial for shaping immunity and
preventing severe COVID-19. We previously demonstrated that injection of pegylated …

COVID-19 complications still present a huge burden on healthcare systems and warrant
predictive risk models to triage patients and inform early intervention. Here, we profile 893 …

Interferons are potent antiviral cytokines that modulate immunity in response to infection or
other danger signals. In addition to their antiviral functions, type I interferons (IFNα and IFNβ) …

Human noroviruses (HuNoVs) are the leading cause of viral gastroenteritis worldwide; yet
currently, no vaccines or FDA-approved antiviral drugs are available to counter these …

While an appropriately regulated production of interferons (IFNs) performs a fundamental
role in the defense against coronaviruses such as severe acute respiratory syndrome …

IFNs are comprised of three families of cytokines that confer protection against pathogen
infection and uncontrolled cellular proliferation. The broad role IFNs play in innate and …

The importance of transcriptional regulation of host genes in innate immunity against viral
infection has been widely recognized. More recently, post-transcriptional regulatory …