[HTML][HTML] Dexmedetomidine: present and future directions
S Lee - Korean journal of anesthesiology, 2019 - ncbi.nlm.nih.gov
Dexmedetomidine is a potent, highly selective α-2 adrenoceptor agonist, with sedative,
analgesic, anxiolytic, sympatholytic, and opioid-sparing properties. Dexmedetomidine …
analgesic, anxiolytic, sympatholytic, and opioid-sparing properties. Dexmedetomidine …
Dexmedetomidine enhances the local anesthetic action of lidocaine via an α-2A adrenoceptor
T Yoshitomi, A Kohjitani, S Maeda… - Anesthesia & …, 2008 - journals.lww.com
BACKGROUND: Clonidine, an α-2 adrenoceptor agonist, is a common adjunct in both
central and peripheral blocks. Dexmedetomidine, a more selective α-2 adrenoceptor …
central and peripheral blocks. Dexmedetomidine, a more selective α-2 adrenoceptor …
新型镇静镇痛药——右美托咪定
易利丹， 彭六保， 谭重庆， 崔巍， 万小敏， 罗霞… - 中国新药与临床 …, 2011 - cqvip.com
右美托咪定是高效, 高选择性的肾上腺素α_2 受体激动药, 具有镇痛作用和剂量依赖性镇静作用.
右美托咪定可单独应用, 也可与咪达唑仑, 丙泊酚或阿片类药物合用, 对呼吸抑制作用小 …
右美托咪定可单独应用, 也可与咪达唑仑, 丙泊酚或阿片类药物合用, 对呼吸抑制作用小 …
The effects of increasing plasma concentrations of dexmedetomidine in humans
Background This study determined the responses to increasing plasma concentrations of
dexmedetomidine in humans. Methods Ten healthy men (20-27 yr) provided informed …
dexmedetomidine in humans. Methods Ten healthy men (20-27 yr) provided informed …
Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements
Purpose: This prospective, randomized, double-blind study was designed to assess whether
intraoperative infusion of dexmedetomidine provides effective postoperative analgesia …
intraoperative infusion of dexmedetomidine provides effective postoperative analgesia …
Dexamethasone is superior to dexmedetomidine as a perineural adjunct for supraclavicular brachial plexus block: systematic review and indirect meta-analysis
E Albrecht, L Vorobeichik… - Anesthesia & …, 2019 - journals.lww.com
BACKGROUND: Both dexamethasone and dexmedetomidine are effective peripheral nerve
block (PNB) perineural adjuncts that prolong block duration. However, each is associated …
block (PNB) perineural adjuncts that prolong block duration. However, each is associated …
Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain
VO Zambelli, ER Gross, CH Chen… - Science translational …, 2014 - science.org
Exogenous aldehydes can cause pain in animal models, suggesting that aldehyde
dehydrogenase-2 (ALDH2), which metabolizes many aldehydes, may regulate nociception …
dehydrogenase-2 (ALDH2), which metabolizes many aldehydes, may regulate nociception …
Morphine reduces local cytokine expression and neutrophil infiltration after incision
JD Clark, X Shi, X Li, Y Qiao, DY Liang… - Molecular …, 2007 - journals.sagepub.com
Background: Inflammation and nociceptive sensitization are hallmarks of tissue surrounding
surgical incisions. Recent studies demonstrate that several cytokines may participate in the …
surgical incisions. Recent studies demonstrate that several cytokines may participate in the …
Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis
Endogenous, descending noradrenergic fibers impose analgesic control over spinal afferent
circuitry mediating the rostrad transmission of pain signals. These fibers target alpha 2 …
circuitry mediating the rostrad transmission of pain signals. These fibers target alpha 2 …
Monoamines as drug targets in chronic pain: focusing on neuropathic pain
Monoamines are involved in regulating the endogenous pain system and indeed, peripheral
and central monoaminergic dysfunction has been demonstrated in certain types of pain …
and central monoaminergic dysfunction has been demonstrated in certain types of pain …