Over the past 2 decades, there has been an extraordinary progress in the regimens
developed for the treatment of human epidermal growth factor receptor 2 (HER2)-positive …

Antibody–drug conjugates (ADCs) are a family of targeted therapeutic agents for the
treatment of cancer. ADC development is a rapidly expanding field of research, with over 80 …

Over the past couple of decades, antibody–drug conjugates (ADCs) have revolutionized the
field of cancer chemotherapy. Unlike conventional treatments that damage healthy tissues …

Drugs, their targets and the nature and number of drug targets | Nature Reviews Drug Discovery
Skip to main content Thank you for visiting nature.com. You are using a browser version with …

Antibody‐dependent cellular cytotoxicity (ADCC) is a set of mechanisms that target cells
coated with IgG antibodies of the proper subclasses (IgG1 in the human) to be the prey of …

Liposomes have gained extensive attention as carriers for a wide range of drugs due to
being both nontoxic and biodegradable as they are composed of substances naturally …

The multichaperone heat shock protein (Hsp) 90 complex mediates the maturation and
stability of a variety of proteins, many of which are crucial in oncogenesis, including …

Allosteric interactions play vital roles in metabolic processes and signal transduction and,
more recently, have become the focus of numerous pharmacological studies because of the …

A wealth of data implicates that ErbB receptors have essential roles in tumor development.
Probiotic bacteria are known to exert an anticancer activity in animal studies. Bacillus …

Learning Objectives After completing this course, the reader will be able to: Describe the
relationship between antibody structure and effector function, and identify strategies for …