Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post …
The SARS-CoV-2 coronavirus continues to evolve with scores of mutations of the spike,
membrane, envelope, and nucleocapsid structural proteins that impact pathogenesis …
membrane, envelope, and nucleocapsid structural proteins that impact pathogenesis …
The power of weak, transient interactions across biology: A paradigm of emergent behavior
A growing list of diverse biological systems and their equally diverse functionalities provides
realizations of a paradigm of emergent behavior. In each of these biological systems …
realizations of a paradigm of emergent behavior. In each of these biological systems …
Allometric comparison of viral dynamics in the nasal cavity-nasopharyngeal mucus layer of human and rhesus monkey by CFD-HCD approach
Background and objective Viral respiratory infections stand as a considerable global health
concern, presenting significant risks to the health of both humans and animals. This study …
concern, presenting significant risks to the health of both humans and animals. This study …
Computational Modeling Insights into Extreme Heterogeneity in COVID-19 Nasal Swab Data
L Zhang, H Cao, K Medlin, J Pearson, AC Aristotelous… - Viruses, 2023 - mdpi.com
Throughout the COVID-19 pandemic, an unprecedented level of clinical nasal swab data
from around the globe has been collected and shared. Positive tests have consistently …
from around the globe has been collected and shared. Positive tests have consistently …
[PDF][PDF] New Challenges in the Mathematical Modelling and Control of COVID-19 Epidemics: Analysis of Non-Pharmaceutical Actions and Vaccination Strategies
CM Verrelli, F Della Rossa - Mathematics, 2024 - mdpi.com
Since its official appearance in China in December 2019, COVID-19 (SARS-CoV-2)
immediately reached pandemic proportions on six continents and in over 195 countries. It …
immediately reached pandemic proportions on six continents and in over 195 countries. It …
Global Sensitivity Analysis of the Onset of Nasal Passage Infection by SARS-CoV-2 With Respect to Heterogeneity in Host Physiology and Host Cell-Virus Kinetic …
L Zhang, H Cao, K Medlin, J Pearson, A Aristotelous… - bioRxiv, 2023 - biorxiv.org
Throughout the COVID-19 pandemic, positive nasal swab tests have revealed dramatic
population heterogeneity in viral titers spanning 6 orders-of-magnitude. Our goal here is to …
population heterogeneity in viral titers spanning 6 orders-of-magnitude. Our goal here is to …