Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell
lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and …

Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …

The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton
(STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for …

Background Atopic dermatitis (AD) is a highly pruritic chronic inflammatory skin disorder.
Ruxolitinib, a selective inhibitor of Janus kinase 1 and Janus kinase 2, potently suppresses …

Atopic dermatitis (AD) is a recurrent, chronic, and inflammatory skin disease, which
processes with severe itchiness. It often coexists with different atopic diseases. The number …

Janus kinase inhibitors (JAKi) belong to a new class of oral targeted disease-modifying
drugs which have recently revolutionized the therapeutic panorama of rheumatoid arthritis …

INTRODUCTION Obesity and its associated complications are serious global concerns.
Despite growing public health initiatives, obesity rates continue to rise. Thus, there is a …

In recent years, the broadening understanding of the pathogenesis of atopic dermatitis (AD)
has led to the development of novel therapeutic molecules, that target core inflammatory …

Interleukin-7 receptor α (IL7R) is required for normal lymphoid development. Loss-of-
function mutations in this gene cause autosomal recessive severe combined immune …

Originally shown to promote the growth and activation of B cells, thymic stromal
lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic …