Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

Homocysteine (Hcy) metabolism is crucial for regulating methionine availability, protein
homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic …

A good nutritional status is important for maintaining normal body function and preventing or
mitigating the dysfunction induced by internal or external factors. Nutritional deficiencies …

Homocysteine (Hcy) is a sulfhydryl-containing amino acid, and intermediate metabolite
formed in metabolising methionine (Met) to cysteine (Cys); defective Met metabolism can …

The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains
unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent …

Diabetes mellitus (DM) can lead to the development of macro-and microvascular
complications. Homocysteine (Hcy) may play a role in the development of cardiovascular …

Homocysteine is a non-proteinogenic sulfhydryl-containing amino acid derived from
methionine and is a homologue of cysteine. The concentration of homocysteine is regulated …

The aggregation of α‐synuclein plays a pivotal role in the pathogenesis of Parkinson's
disease (PD). Epidemiological evidence indicates that high level of homocysteine (Hcy) is …

Diabetic retinopathy (DR) is a form of microangiopathy. Reducing oxidative stress in the
mitochondria and cell membranes decreases ischemic injury and end-organ damage to the …