Significance: Organisms adapt to changing environments by engaging cellular stress
response pathways that serve to restore proteostasis and enhance survival. A primary …

The integrated stress response (ISR) refers to signaling pathways initiated by stress-
activated eIF2α kinases. Distinct eIF2α kinases respond to different stress signals, including …

Metabolic networks are interconnected and influence diverse cellular processes. The protein-
metabolite interactions that mediate these networks are frequently low affinity and …

Non-alcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome,
and is estimated to affect one billion individuals worldwide. An increased intake of a high-fat …

Eukaryotic initiation factor 2B, eIF2B is a guanine nucleotide exchange, factor with a central
role in coordinating the initiation of translation. During stress and disease, the activity of …

Control of protein synthesis (mRNA translation) plays key roles in shaping the proteome and
in many physiological, including homeostatic, responses. One long-known translational …

The Integrated Stress Response (ISR) is an essential homeostatic signaling network that
controls the cell's biosynthetic capacity. Four ISR sensor kinases detect multiple stressors …

Metabolism is highly interconnected and also has profound effects on other cellular
processes. However, the interactions between metabolites and proteins that mediate this …

In eukaryotic cells, stressors reprogram the cellular proteome by activating the integrated
stress response (ISR). In its canonical form, stress-sensing kinases phosphorylate the …

The integrated stress response (ISR) protects cells from a variety of insults. Once elicited
(eg, by virus infections), it eventually leads to the block of mRNA translation. Central to the …