Safety and tolerance of d, l-methadone in combination with chemotherapy in patients with glioma

J Onken, C Friesen, P Vajkoczy, M Misch - Anticancer Research, 2017 - ar.iiarjournals.org
Background/Aim: D, L-Methadone increases sensitivity toward chemotherapy of different
tumor cell populations. We evaluated the safety and tolerance of additional use of D, L …

Against repurposing methadone for glioblastoma therapy

T Vatter, L Klumpp, K Ganser, N Stransky, D Zips… - Biomolecules, 2020 - mdpi.com
Methadone, which is used as maintenance medication for outpatient treatment of opioid
dependence or as an analgesic drug, has been suggested by preclinical in vitro and mouse …

Efficacy of D,L-methadone in the treatment of glioblastoma in vitro

K Brawanski, G Brockhoff, P Hau… - CNS …, 2018 - Taylor & Francis
Aim: Recently, D, L-methadone has been put forward as adjuvant treatment in glioblastoma
(GBM). Methods: We analyzed the μ-opioid receptor expression in a set of GBM cell lines …

[HTML][HTML] Methadone concentrations in exhaled breath condensate, serum and urine of patients under maintenance treatment

M Khoubnasabjafari, K Ansarin… - Iranian Journal of …, 2017 - ncbi.nlm.nih.gov
Drug abuse is a serious problem causing health, economical and psycho-social negative
outcomes. Methadone is commonly used drug for management of drug addiction. Exhaled …

Quantitation of methadone and metabolite in patients under maintenance treatment

SH Diong, NS Mohd Yusoff, MS Sim… - Journal of analytical …, 2014 - academic.oup.com
Gas chromatography–mass spectrometry quantitative method was developed to monitor
concentrations of methadone and its metabolite 2-ethylidene-1, 5-dimethyl-3, 3 …

[HTML][HTML] An efficient and smooth methadone-to-buprenorphine transition protocol utilizing a transdermal fentanyl bridge and a pharmacokinetic inducer: the Stanciu …

CN Stanciu, S Gibson, N Teja, CJ Healey - Cureus, 2020 - ncbi.nlm.nih.gov
The traditional method of transitioning from methadone to buprenorphine requires a gradual
dose reduction to a low dose of 30 mg daily, followed by cessation, and addressing …

Dose, plasma level, and treatment outcome among methadone patients in Shanghai, China

H Jiang, M Hillhouse, J Du, S Pan, A Alfonso… - Neuroscience …, 2016 - Springer
The purpose of this study was to investigate the blood levels of methadone in participants
receiving methadone for the treatment of opioid dependence. After stabilization on …

Can saliva and plasma methadone concentrations be used for enantioselective pharmacokinetic and pharmacodynamic studies in patients with advanced cancer?

R George, A Haywood, P Good, S Hennig, S Khan… - Clinical Therapeutics, 2017 - Elsevier
Purpose Methadone is a potent analgesic used to treat refractory cancer pain. It is
administered as a racemic mixture, with the l-enantiomer being primarily a μ-receptor …

Drug testing in addiction medicine

C Tremonti, PS Haber - Textbook of Addiction Treatment: International …, 2021 - Springer
Drug testing in addiction medicine is typically carried out via either immunoassay, such as in
urine drug screens, or gas chromatography mass spectrometry (GCMS). Immunoassays are …

16 The (Lack of) Benefit of

R Ervin, P Padmanabhan - Medical Toxicology, 2024 - books.google.com
Background The National Institute on Drug Abuse (NIDA) was founded in 1974 in response
to rising substance use in the 1960s. Its original mission centered around identifying illicit …