Novel agents for the pharmacological treatment of alcohol use disorder
Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …
A balancing act: The role of pro‐and anti‐stress peptides within the central amygdala in anxiety and alcohol use disorders
LC Walker - Journal of neurochemistry, 2021 - Wiley Online Library
The central nucleus of the amygdala (CeA) is widely implicated as a structure that integrates
both appetitive and aversive stimuli. While intrinsic CeA microcircuits primarily consist of …
both appetitive and aversive stimuli. While intrinsic CeA microcircuits primarily consist of …
A sleeping giant: Suvorexant for the treatment of alcohol use disorder?
There are currently 3 FDA approved treatments for alcohol use disorder (AUD) in the USA,
opioid receptor antagonists such as naltrexone, disulfiram and acamprosate. To date, these …
opioid receptor antagonists such as naltrexone, disulfiram and acamprosate. To date, these …
Investigational drugs for alcohol use disorders: a review of preclinical data
SS Ch'Ng, AJ Lawrence - Expert opinion on investigational drugs, 2018 - Taylor & Francis
ABSTRACT Introduction: Alcohol use disorders (AUDs) are one of the leading causes of
preventable death in the developed world. In the US, only three FDA-approved …
preventable death in the developed world. In the US, only three FDA-approved …
Orexin-mediated Motivated Arousal and Reward Seeking.
TE Bjorness, RW Greene - Peptides, 2024 - Elsevier
The neuromodulator orexin has been identified as a key factor for motivated arousal
including recent evidence that sleep deprivation-induced enhancement of reward behavior …
including recent evidence that sleep deprivation-induced enhancement of reward behavior …
Orexinergic lateral hypothalamus (LH) projections to medial septum (MS) modulate ethanol-induced sedation in male and female mice and binge-like ethanol drinking …
SC Bendrath, CA Cook, DJ Knapp, TE Thiele - Alcohol, 2024 - Elsevier
Orexin in both the lateral hypothalamus (LH) and medial septum (MS) is involved in sleep-
and consciousness-related conditions. Since orexin modulates the intoxicating as well as …
and consciousness-related conditions. Since orexin modulates the intoxicating as well as …
The regulatory role of Neurotransmitters in Orexin B induced Nucleus Accumbens dependent alcohol ingestion in Wistar albino rats
KS Rashmi, SK Maynnavar… - Research Journal of …, 2020 - indianjournals.com
Objective: The Present study mainly focussed on the influential role of local neurotransmitter
level in Orexin B induced Nucleus Accumbens (NAc) dependent voluntary ethanol …
level in Orexin B induced Nucleus Accumbens (NAc) dependent voluntary ethanol …