Can classical and modern chemical C− H oxidation reactions complement biotransformation
in the synthesis of drug metabolites? We have surveyed the literature in an effort to try to …

Introduction: Fluorine's unique physicochemical properties make it a key element for
incorporation into pharmacologically active compounds. Its presence in a drug can alter a …

The excesses of reagents used in protein chemistry are often incompatible with the reduced
or even inverse stoichiometries used for efficient radiolabeling. Analysis and screening of …

Cunninghamella elegans is a long-established microbial model of mammalian drug and
xenobiotic metabolism enabled by the actions of cytochrome P450 enzymes that are poorly …

A metal-free route based on a carbon catalyst to synthesize biphenyls through oxidative
dehydrogenation (ODH) of phenyl cyclohexene has been investigated. Among the samples …

The metabolism and polarity of the all-cis tetra-fluorocyclohexane motif is explored in the
context of its potential as a motif for inclusion in drug discovery programmes …

Several wild type and recombinant microorganisms can transform drugs to the equivalent
human metabolites. Fungi, such as Cunninghamella spp., and Streptomyces bacteria …

Multiple technologies have emerged for structural diversification and efficient production of
metabolites of drug molecules. These include expanded use of enzymatic and bioorganic …

A Au-catalyzed versatile and efficient access to 1 H-isochromenes is reported. The efficiency
of the [AuCl2 (Pic)] complex (1–5 mol%) was demonstrated and allowed a domino …

The isolation, quantitation, and characterization of drug metabolites in biological fluids
remain challenging. Rapid access to oxidized drugs could facilitate metabolite identification …