COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression
NV Chandrasekharan, H Dai… - Proceedings of the …, 2002 - National Acad Sciences
Two cyclooxygenase isozymes, COX-1 and-2, are known to catalyze the rate-limiting step of
prostaglandin synthesis and are the targets of nonsteroidal antiinflammatory drugs. Here we …
prostaglandin synthesis and are the targets of nonsteroidal antiinflammatory drugs. Here we …
[PDF][PDF] Cyclooxygenase-3: axiom, dogma, anomaly, enigma or splice error? Not as easy as 1, 2, 3
A continued need to develop safe and effective analgesics and anti-inflammatory drugs fuels
the ongoing investigations of cyclooxygenase (COX). In addition, a long unanswered …
the ongoing investigations of cyclooxygenase (COX). In addition, a long unanswered …
COX-3: just another COX or the solitary elusive target of paracetamol?
In 1899, acetylsalicylic acid, aspirin, was one of the first analgesic and anti-inflammatory
drugs. However, it took a further 70 years and at least a dozen new drugs, many of which are …
drugs. However, it took a further 70 years and at least a dozen new drugs, many of which are …
Inhibition of PTGS1 promotes osteogenic differentiation of adipose-derived stem cells by suppressing NF-kB signaling
Y Wang, Y Liu, M Zhang, L Lv, X Zhang… - Stem Cell Research & …, 2019 - Springer
Background Tissue inflammation is an important problem in the field of human adipose-
derived stem cell (ASC)-based therapeutic bone regeneration. Many studies indicate that …
derived stem cell (ASC)-based therapeutic bone regeneration. Many studies indicate that …
COX-3 the enzyme and the concept: steps towards highly specialized pathways and precision therapeutics?
JM Schwab, HJ Schluesener, R Meyermann… - … and Essential fatty acids, 2003 - Elsevier
Cyclooxygenases (COXs) catalyse the key rate-limiting step in prostanoid and thromboxane
biosynthesis and are targets of non-steroidal anti-inflammatory drugs (NSAIDs). Until …
biosynthesis and are targets of non-steroidal anti-inflammatory drugs (NSAIDs). Until …
[引用][C] Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition
DL Simmons, RM Botting, T Hla - Pharmacological reviews, 2004 - ASPET
ZBTB46, SPDEF, and ETV6: Novel Potential Biomarkers and Therapeutic Targets in Castration-Resistant Prostate Cancer
AFS Fararjeh, YN Liu - International Journal of Molecular Sciences, 2019 - mdpi.com
Prostate cancer (PCa) is the second most common killer among men in Western countries.
Targeting androgen receptor (AR) signaling by androgen deprivation therapy (ADT) is the …
Targeting androgen receptor (AR) signaling by androgen deprivation therapy (ADT) is the …
Regulation of bone biology by prostaglandin endoperoxide H synthases (PGHS): A rose by any other name…
L Li, AR Pettit, LS Gregory, MR Forwood - Cytokine & growth factor reviews, 2006 - Elsevier
It is well established that prostaglandins are essential mediators of bone resorption and
formation. In the early 1990s, it was discovered that enzymatic reactions producing …
formation. In the early 1990s, it was discovered that enzymatic reactions producing …
Regulation of genes in the arachidonic acid metabolic pathway by RNA processing and RNA‐mediated mechanisms
CS Lutz, AL Cornett - Wiley Interdisciplinary Reviews: RNA, 2013 - Wiley Online Library
Arachidonic acid (AA) is converted by enzymes in an important metabolic pathway to
produce molecules known collectively as eicosanoids, 20 carbon molecules with significant …
produce molecules known collectively as eicosanoids, 20 carbon molecules with significant …