[HTML][HTML] Human papillomavirus genome variants

RD Burk, A Harari, Z Chen - Virology, 2013 - Elsevier
Amongst the human papillomaviruses (HPVs), the genus Alphapapillomavirus contains HPV
types that are uniquely pathogenic. They can be classified into species and types based on …

Human papillomavirus genomics: Understanding carcinogenicity

CW Nelson, L Mirabello - Tumour Virus Research, 2023 - Elsevier
Human papillomavirus (HPV) causes virtually all cervical cancers and many cancers at other
anatomical sites in both men and women. However, only 12 of 448 known HPV types are …

[HTML][HTML] Evolution of the papillomaviridae

K Van Doorslaer - Virology, 2013 - Elsevier
Viruses belonging to the Papillomaviridae family have been isolated from a variety of
mammals, birds and non-avian reptiles. It is likely that most, if not all, amniotes carry a broad …

HPV16 sublineage associations with histology-specific cancer risk using HPV whole-genome sequences in 3200 women

L Mirabello, M Yeager, M Cullen… - JNCI: Journal of the …, 2016 - academic.oup.com
Background: HPV16 is a common sexually transmitted infection although few infections lead
to cervical precancer/cancer; we cannot distinguish nor mechanistically explain why only …

Human papillomavirus type 16 genetic variants: phylogeny and classification based on E6 and LCR

I Cornet, T Gheit, S Franceschi, J Vignat… - Journal of …, 2012 - Am Soc Microbiol
Naturally occurring genetic variants of human papillomavirus type 16 (HPV16) are common
and have previously been classified into 4 major lineages; European-Asian (EAS), including …

HPV16 genetic variation and the development of cervical cancer worldwide

I Cornet, T Gheit, MR Iannacone, J Vignat… - British journal of …, 2013 - nature.com
Background: Factors that favour a small proportion of HPV16 infections to progress to cancer
are still poorly understood, but several studies have implicated a role of HPV16 genetic …

Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance

B Zhu, Y Xiao, M Yeager, G Clifford… - Nature …, 2020 - nature.com
HPV16 causes half of cervical cancers worldwide; for unknown reasons, most infections
resolve within two years. Here, we analyze the viral genomes of 5,328 HPV16-positive case …

[HTML][HTML] HPV infections—classification, pathogenesis, and potential new therapies

B Mlynarczyk-Bonikowska, L Rudnicka - International Journal of …, 2024 - mdpi.com
To date, more than 400 types of human papillomavirus (HPV) have been identified. Despite
the creation of effective prophylactic vaccines against the most common genital HPVs, the …

Human papillomavirus genomics: past, present and future

A Harari, Z Chen, RD Burk - Human papillomavirus, 2014 - karger.com
Human papillomaviruses (HPV) are a group of divergent DNA viruses, of which a select few
evolutionarily related HPVs have emerged to be highly oncogenic and of significant medical …

[HTML][HTML] Deep sequencing of HPV16 genomes: A new high-throughput tool for exploring the carcinogenicity and natural history of HPV16 infection

M Cullen, JF Boland, M Schiffman, X Zhang… - Papillomavirus …, 2015 - Elsevier
For unknown reasons, there is huge variability in risk conferred by different HPV types and,
remarkably, strong differences even between closely related variant lineages within each …