Recent advances in lentiviral vector development and applications
J Mátrai, MKL Chuah, T VandenDriessche - Molecular therapy, 2010 - cell.com
Lentiviral vectors (LVs) have emerged as potent and versatile vectors for ex vivo or in vivo
gene transfer into dividing and nondividing cells. Robust phenotypic correction of diseases …
gene transfer into dividing and nondividing cells. Robust phenotypic correction of diseases …
[HTML][HTML] Targeting FTO suppresses cancer stem cell maintenance and immune evasion
Fat mass and obesity-associated protein (FTO), an RNA N 6-methyladenosine (m 6 A)
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
Production of CAR T-cells by GMP-grade lentiviral vectors: latest advances and future prospects
Chimeric antigen receptor (CAR) T-cells represent a paradigm shift in cancer
immunotherapy and a new milestone in the history of oncology. In 2017, the Food and Drug …
immunotherapy and a new milestone in the history of oncology. In 2017, the Food and Drug …
A comprehensive library of human transcription factors for cell fate engineering
AHM Ng, P Khoshakhlagh, JE Rojo Arias… - Nature …, 2021 - nature.com
Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse
cell types and tissues. To enable systematic exploration of the programming landscape …
cell types and tissues. To enable systematic exploration of the programming landscape …
HIV vaccine design to target germline precursors of glycan-dependent broadly neutralizing antibodies
Broadly neutralizing antibodies (bnAbs) against the N332 supersite of the HIV envelope
(Env) trimer are the most common bnAbs induced during infection, making them promising …
(Env) trimer are the most common bnAbs induced during infection, making them promising …
[HTML][HTML] Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors
Broadly neutralizing antibodies (bnAbs) to the HIV envelope (Env) V2-apex region are
important leads for HIV vaccine design. Most V2-apex bnAbs engage Env with an …
important leads for HIV vaccine design. Most V2-apex bnAbs engage Env with an …
Transcriptome-wide sites of collided ribosomes reveal principles of translational pausing
Translation initiation is the major regulatory step defining the rate of protein production from
an mRNA. Meanwhile, the impact of nonuniform ribosomal elongation rates is largely …
an mRNA. Meanwhile, the impact of nonuniform ribosomal elongation rates is largely …
Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells
Circadian cycles and cell cycles are two fundamental periodic processes with a period in the
range of 1 day. Consequently, coupling between such cycles can lead to synchronization …
range of 1 day. Consequently, coupling between such cycles can lead to synchronization …
UTX/KDM6A loss enhances the malignant phenotype of multiple myeloma and sensitizes cells to EZH2 inhibition
T Ezponda, D Dupéré-Richer, CM Will, EC Small… - Cell reports, 2017 - cell.com
Loss or inactivation of the histone H3K27 demethylase UTX occurs in several malignancies,
including multiple myeloma (MM). Using an isogenic cell system, we found that loss of UTX …
including multiple myeloma (MM). Using an isogenic cell system, we found that loss of UTX …
The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons
PTEN-induced putative kinase 1 (PINK1) and Parkin act in a common pathway to regulate
mitochondrial dynamics, the involvement of which in the pathogenesis of Parkinson's …
mitochondrial dynamics, the involvement of which in the pathogenesis of Parkinson's …