The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine

P Kumar, S Kandoi, R Misra, S Vijayalakshmi… - Cytokine & growth factor …, 2019 - Elsevier
Abstract Mesenchymal Stem Cells (MSCs) have been shown to be a promising candidate for
cell-based therapy. The therapeutic potential of MSCs, towards tissue repair and wound …

[HTML][HTML] Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC

R Hass, C Kasper, S Böhm, R Jacobs - Cell Communication and Signaling, 2011 - Springer
The mesenchymal stroma harbors an important population of cells that possess stem cell-
like characteristics including self renewal and differentiation capacities and can be derived …

[HTML][HTML] iPSC-MSCs with high intrinsic MIRO1 and sensitivity to TNF-α yield efficacious mitochondrial transfer to rescue anthracycline-induced cardiomyopathy

Y Zhang, Z Yu, D Jiang, X Liang, S Liao, Z Zhang… - Stem cell reports, 2016 - cell.com
Mesenchymal stem cells (MSCs) can donate mitochondria and rescue anthracycline-
induced cardiomyocyte (CM) damage, although the underlying mechanisms remain elusive …

Concise review: induced pluripotent stem cell‐derived mesenchymal stem cells: progress toward safe clinical products

Y Jung, G Bauer, JA Nolta - Stem cells, 2012 - academic.oup.com
Adult stem cell therapies have provided success for more than 50 years, through
reconstitution of the hematopoietic system using bone marrow, umbilical cord blood, and …

Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice

YQ Sun, MX Deng, J He, QX Zeng, W Wen… - Stem …, 2012 - academic.oup.com
We previously found that mesenchymal stem cells (MSCs) derived from human-induced
pluripotent stem cells (iPSCs) exerted immunomodulatory effects on Th2-mediated allergic …

Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties

EA Kimbrel, NA Kouris, GJ Yavanian, J Chu… - Stem cells and …, 2014 - liebertpub.com
Mesenchymal stem cells (MSCs) are being tested in a wide range of human diseases;
however, loss of potency and inconsistent quality severely limit their use. To overcome these …

[HTML][HTML] Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia

A Liew, T O'Brien - Stem cell research & therapy, 2012 - Springer
The therapeutic potential of mesenchymal stem cell (MSC) transplantation for the treatment
of ischemic conditions such as coronary artery disease, peripheral arterial disease, and …

[HTML][HTML] Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of multiple sclerosis

X Wang, EA Kimbrel, K Ijichi, D Paul, AS Lazorchak… - Stem cell reports, 2014 - cell.com
Current therapies for multiple sclerosis (MS) are largely palliative, not curative.
Mesenchymal stem cells (MSCs) harbor regenerative and immunosuppressive functions …

Engineering bone tissue from human embryonic stem cells

D Marolt, IM Campos, S Bhumiratana… - Proceedings of the …, 2012 - National Acad Sciences
In extensive bone defects, tissue damage and hypoxia lead to cell death, resulting in slow
and incomplete healing. Human embryonic stem cells (hESC) can give rise to all specialized …

Review of vascularised bone tissue‐engineering strategies with a focus on co‐culture systems

Y Liu, JKY Chan, SH Teoh - Journal of tissue engineering and …, 2015 - Wiley Online Library
Poor angiogenesis within tissue‐engineered grafts has been identified as a main challenge
limiting the clinical introduction of bone tissue‐engineering (BTE) approaches for the repair …