Impaired clearance of apoptotic cell material has been implicated in the pathogenesis of
systemic lupus erythematosus (SLE). Besides many other molecules, C1q and DNaseI …

Systemic lupus erythematosus is an autoimmune disease of unknown etiology. Research
efforts of the last few years have mainly focused on basic molecular and cellular …

The OVA 323–339 epitope recognized by DO11. 10 (H-2 d) and OT-II (H-2 b) T cells was
investigated using amino-and carboxy-terminal truncations to locate the approximate ends …

The level of proteolysis within phagosomes of dendritic cells (DCs) is thought to be tightly
regulated, as it directly impacts the cell's efficiency to process antigen. Activity of the …

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract viral disease
in infants and young children. Presently, there are no explicit recommendations for RSV …

Peptides bind to MHC class II molecules with a defined periodicity such that the peptide-
flanking residues (PFRs) P-1 and P11, which lie outside the core binding sequence (P1 …

MHC class II heterodimers bind peptides 12–20 aa in length. The peptide flanking residues
(PFRs) of these ligands extend from a central binding core consisting of nine amino acids …

Apoptosis is a physiological form of cell death required to ensure that the rate of cell division
is balanced by the rate of cell death in multicellular organisms. Dysregulation of apoptosis is …

Previous studies suggested that tetanus and diphtheria toxoids (TTD and DTD, respectively)
contain “universal” epitopes for human CD4+ cells (residues 632–651 and 950–969 of TTD …

Immunodominance refers to the restricted antigen specificity of T cells detected in the
immune response after immunization with complex antigens. Despite the presence of many …