Ocular diseases associated with retinal ganglion cell (RGC) degeneration is the most
common neurodegenerative disorder that causes irreversible blindness worldwide. It is …

Background: Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) is the second most
common cause of optic nerve-related permanent visual loss in adults. Aim: We aimed to …

The majority of patients with diabetic macular edema (DME), the most common cause of
vision loss in working-age Americans, do not respond adequately to current therapies …

The Rho kinase (ROCK) signaling pathway is involved in several cellular events that include
cell proliferation and cytoskeleton modulation leading to cell adhesion. The ROCK pathway …

Background Nonarteritic anterior ischemic optic neuropathy (NAAION) is a major cause of
blindness in individuals over 50 years of age, with no available effective treatment. The oral …

NAION is a common cause of acute vision loss in adult and older patients, and thus,
comprehensive ophthalmologists need to be able to diagnose and appropriately manage …

Currently, corneal blindness is affecting> 10 million individuals worldwide, and there is a
significant unmet medical need because only 1.5% of transplantation needs are met globally …

The Rho-kinase/ROCK (Rho-associated coiled-coil-containing protein kinase) pathway is
involved in the pathogenesis of multiple ocular and systemic disorders. Recently, ROCK …

Nonarteritic anterior ischemic optic neuropathy (NAION) refers to a presumed ischemic
process of the anterior portion of the optic nerve. Although many associations with NAION …

Purpose: Retinal detachment disrupts the rod-bipolar synapse in the outer plexiform layer by
retraction of rod axons. We showed that breakage is due to RhoA activation whereas …