Antimicrobial Resistance (AMR) raises a serious concern as it contributes to the global
mortality by 5 million deaths per year. The overall impact pertaining to significant membrane …

Multidrug resistance (MDR) proteins belonging to the ATP-Binding Cassette (ABC)
transporter group play a crucial role in the export of cytotoxic drugs across cell membranes …

While it is known that lipids play an essential role in regulating membrane protein structure
and function, it remains challenging to identify specific protein–lipid interactions. Here, we …

Lipopolysaccharide (LPS) is vital for maintaining the outer membrane barrier in Gram-
negative bacteria. LPS is also frequently obtained in complex with the inner membrane …

Structural and functional studies of the ATP-binding cassette transporter MsbA have
revealed two distinct lipopolysaccharide (LPS) binding sites: one located in the central cavity …

Electron capture dissociation (ECD) is now a well-established method for sequencing
peptides and performing top-down analysis on proteins of less than 30 kDa, and there is …

The ABC transporter MsbA plays a critical role in Gram-negative bacteria in the regulation of
the outer membrane by translocating core-LPS across the inner membrane. Additionally, a …

The ATP-binding cassette (ABC) transporter, MsbA, plays a pivotal role in
lipopolysaccharide (LPS) biogenesis by facilitating the transport of the LPS precursor …

The structural determination and characterization of molecules, namely proteins and
enzymes, is crucial to gaining a better understanding of their role in different chemical and …

TREK2, a two-pore domain potassium channel, is recognized for its regulation by various
stimuli, including lipids. While previous members of the TREK subfamily, TREK1 and …