Advanced operating strategies to extend the applications of simulated moving bed chromatography
Chromatographic separation with solid stationary and fluid mobile phases is widely used to
isolate and purify compounds. One of the most productive improvements in preparative …
isolate and purify compounds. One of the most productive improvements in preparative …
Fructooligosaccharides production and the health benefits of prebiotics
Dietary prebiotics have been associated with the prevention and treatment of many 21st-
century diseases. Prebiotics' health benefits have been linked to microbiome–host complex …
century diseases. Prebiotics' health benefits have been linked to microbiome–host complex …
Automatic control of simulated moving bed process with deep Q-network
Optimal control of a simulated moving bed (SMB) process is challenging because the
system dynamics is represented as nonlinear partial differential-algebraic equations …
system dynamics is represented as nonlinear partial differential-algebraic equations …
One-step co-culture fermentation strategy to produce high-content fructo-oligosaccharides
C Nobre, DA Gonçalves, JA Teixeira… - Carbohydrate …, 2018 - Elsevier
An integrated process enabling the simultaneous production and purification of fructo-
oligosaccharides (FOS) was explored. A co-culture fermentation with Aspergillus ibericus …
oligosaccharides (FOS) was explored. A co-culture fermentation with Aspergillus ibericus …
Advanced control strategies for the multicolumn countercurrent solvent gradient purification process
MM Papathanasiou, S Avraamidou… - AIChE …, 2016 - Wiley Online Library
The multicolumn countercurrent solvent gradient purification process (MCSGP) is a
semicontinuous, chromatographic separation process used in the production of monoclonal …
semicontinuous, chromatographic separation process used in the production of monoclonal …
Assisting continuous biomanufacturing through advanced control in downstream purification
Aiming to significantly improve their processes and secure market share, monoclonal
antibody (mAb) manufacturers seek innovative solutions that will yield improved production …
antibody (mAb) manufacturers seek innovative solutions that will yield improved production …
Successive Fermentation of Aguamiel and Molasses by Aspergillus oryzae and Saccharomyces cerevisiae to Obtain High Purity Fructooligosaccharides
Fructooligosaccharides (FOS) are usually synthesized with pure enzymes using highly
concentrated sucrose solutions. In this work, low-cost aguamiel and molasses were …
concentrated sucrose solutions. In this work, low-cost aguamiel and molasses were …
Nonlinear model predictive control applied to the separation of praziquantel in simulated moving bed chromatography
An adaptive nonlinear model predictive control of a simulated moving bed unit for the
enantioseparation of praziquantel is presented. A first principle model was applied at the …
enantioseparation of praziquantel is presented. A first principle model was applied at the …
Purity control of simulated moving bed based on advanced fuzzy controller
CF Xie, X Chen, H Zhang - Scientific Reports, 2024 - nature.com
Simulated moving bed (SMB) technology is considered one of the most successful
techniques in chromatographic separation. However, due to the nonlinearity caused by …
techniques in chromatographic separation. However, due to the nonlinearity caused by …
[HTML][HTML] Moving horizon estimation and control of a binary simulated moving bed chromatographic processes with Langmuir isotherms
Simulated moving bed chromatographic (SMB) chromatographic processes are widely used
for separations in pharmaceutical and biotechnological industries. In the present work, the …
for separations in pharmaceutical and biotechnological industries. In the present work, the …