The majority of activated B cells differentiate into IgA plasma cells, with the gut being the
largest producer of immunoglobulin in the body. Secretory IgA antibodies have numerous …

Invading pathogens have unique molecular signatures that are recognized by Toll‐like
receptors (TLRs) resulting in either activation of antigen‐presenting cells (APCs) and/or …

Summary CD4+ Foxp3-expressing Treg cells, which constitutively express the inhibitory
coreceptor CTLA-4, are indispensable for immune homeostasis. We determined the roles of …

At sites of inflammation, certain regulatory T cells (Treg cells) can undergo rapid
reprogramming into helper-like cells without loss of the transcription factor Foxp3. We show …

Here, we test the role of FoxP3+ regulatory T cells (Tregs) in controlling T follicular helper
(Tfh) and germinal centre (GC) B-cell responses to influenza. In contrast to the idea that …

The subpopulation of CD4+ T lymphocytes that co-express the transcription factor Foxp3
plays a unique role as regulatory T lymphocytes (Tregs) that modulate many aspects of the …

Recent successes in immune therapeutic strategies aimed to improve control over tumor
growth have sparked hope that long-lived control of cancer through stimulation of the …

Decreasing the incidence of chronic rejection and reducing the need for life-long
immunosuppression remain important goals in clinical transplantation. In this article, we will …

T follicular regulatory cells, or Tfr cells, are a discernable population of regulatory T (Treg)
cells that migrate to the B cell follicle and germinal center (GC) upon immune challenge …

Foxp3-lineage CD4 regulatory T cells (Tregs) were named for their ability to maintain self
tolerance and suppress T cell immunity. However, resting Tregs from noninflamed tissues …