Although it has long been recognized that the exonucleolytic proofreading activity intrinsic to
the replicative DNA polymerases Pol δ and Pol ε is essential for faithful replication of DNA …

The evolutionarily conserved human polymerase delta (POLD1) gene encodes the large
p125 subunit which provides the essential catalytic activities of polymerase δ (Polδ) …

Background: Current risk stratification in endometrial cancer (EC) results in frequent over-
and underuse of adjuvant therapy, and may be improved by novel biomarkers. We …

The germline mutation rate is an important parameter that affects the amount of genetic
variation and the rate of evolution. However, neither the rate of germline mutations in …

Fidelity of DNA replication is maintained using polymerase proofreading and the mismatch
repair pathway. Tumors with loss of function of either mechanism have elevated mutation …

The mutator phenotype hypothesis was postulated more than 40 years ago. It was based on
the multiple enzymatic steps required to precisely replicate the 6 billion bases in the human …

DNA polymerases are uniquely poised to contribute to the elevated mutation burdens seen
in many human tumors. These mutations can arise through a number of different polymerase …

Accurate DNA replication of an undamaged template depends on polymerase selectivity for
matched nucleotides, exonucleolytic proofreading of mismatches, and removal of remaining …

It has been over a decade since the initial identification of exonuclease domain mutations in
the genes encoding the catalytic subunits of replication DNA polymerases ϵ and δ (POLE …

Cancer is instigated by mutator phenotypes, including deficient mismatch repair and p53-
associated chromosomal instability. More recently, a distinct class of cancers was identified …