The interaction between histones and DNA is important for eukaryotic gene expression. A
loose interaction caused, for example, by the neutralization of a positive charge on the …

Simple Summary Beyond mutations, epigenetic changes have been described as drivers for
cancer as well. While leaving the overall DNA structure intact, they can be responsible for …

Epigenetic enzymes are often dysregulated in human tumors through mutation, altered
expression, or inappropriate recruitment to certain loci. The identification of these enzymes …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …

We report crystal structures of zebrafish histone deacetylase 6 (HDAC6) catalytic domains in
tandem or as single domains in complex with the (R) and (S) enantiomers of trichostatin A …

Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in
numerous biological processes, largely through their repressive influence on transcription …

The broad study of histone deacetylases in chemistry, biology and medicine relies on tool
compounds to derive mechanistic insights. A phylogenetic analysis of class I and II histone …

Summary Class IIa histone deacetylases (HDACs) are signal-dependent modulators of
transcription with established roles in muscle differentiation and neuronal survival. We show …

Recent studies on enzymes and reader proteins for histone crotonylation support a function
of histone crotonylation in transcription. However, the enzyme (s) responsible for histone …