Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle

JV Andersen, A Schousboe, A Verkhratsky - Progress in neurobiology, 2022 - Elsevier
Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis

Q Zhang, R Abdo, C Iosef, T Kaneko… - Nature …, 2022 - nature.com
Brain metastases (BrMs) are a common occurrence in lung cancer with a dismal outcome.
To understand the mechanism of metastasis to inform prognosis and treatment, here we …

Pericytes in the disease spotlight

H van Splunder, P Villacampa, A Martínez-Romero… - Trends in Cell …, 2024 - cell.com
Pericytes are known as the mural cells in small-caliber vessels that interact closely with the
endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when …

Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies

I Lurje, NT Gaisa, R Weiskirchen, F Tacke - Molecular Aspects of Medicine, 2023 - Elsevier
Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …

Molecular anatomy of adult mouse leptomeninges

R Pietilä, F Del Gaudio, L He, E Vázquez-Liébanas… - Neuron, 2023 - cell.com
Leptomeninges, consisting of the pia mater and arachnoid, form a connective tissue
investment and barrier enclosure of the brain. The exact nature of leptomeningeal cells has …

Fibroblast and myofibroblast activation in normal tissue repair and fibrosis

FS Younesi, AE Miller, TH Barker, FMV Rossi… - … Reviews Molecular Cell …, 2024 - nature.com
The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

Living on the edge of the CNS: meninges cell diversity in health and disease

J Derk, HE Jones, C Como, B Pawlikowski… - Frontiers in cellular …, 2021 - frontiersin.org
The meninges are the fibrous covering of the central nervous system (CNS) which contain
vastly heterogeneous cell types within its three layers (dura, arachnoid, and pia). The dural …

[HTML][HTML] Pericytes in the tumor microenvironment

Z Jiang, J Zhou, L Li, S Liao, J He, S Zhou, Y Zhou - Cancer letters, 2023 - Elsevier
Pericytes are a type of mural cell located between the endothelial cells of capillaries and the
basement membrane, which function to regulate the capillary vasomotor and maintain …

Pathophysiology, classification and comorbidities after traumatic spinal cord injury

J Guest, N Datta, G Jimsheleishvili… - Journal of personalized …, 2022 - mdpi.com
The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing
communication between the brain and the rest of the body, conveying complex sensory and …