Effect of saffron, black seed, and their main constituents on inflammatory cytokine response (mainly TNF-α) and oxidative stress status: An aspect on pharmacological …

Z Vafaeipour, M Ghasemzadeh Rahbardar… - Naunyn-Schmiedeberg's …, 2023 - Springer
Tumor necrosis factor-α (TNF-α), an inflammatory cytokine, is produced by monocytes and
macrophages. It is known as a'double-edged sword'because it is responsible for …

Adrenomedullin mitigates doxorubicin-induced nephrotoxicity in rats: role of oxidative stress, inflammation, apoptosis, and pyroptosis

RN Abd-Ellatif, NA Nasef, HES El-Horany… - International Journal of …, 2022 - mdpi.com
Doxorubicin (DOX) is an anticancer antibiotic which has various effects in human cancers. It
is one of the commonly known causes of drug-induced nephrotoxicity, which results in acute …

Betaine alleviates doxorubicin‐induced nephrotoxicity by preventing oxidative insults, inflammation, and fibrosis through the modulation of Nrf2/HO− 1/NLRP3 and …

D Patel, P Yadav, SK Singh, SS Tanwar… - … of Biochemical and …, 2024 - Wiley Online Library
Doxorubicin (Dox) is an anthracycline antibiotic used to treat various cancers and shows
severe toxicity in multiple organ systems, including kidneys. Evidence shows that betaine's …

Emerging insights into the role of NLRP3 inflammasome and endoplasmic reticulum stress in renal diseases

Y Zhang, S Guo, X Fu, Q Zhang, H Wang - International …, 2024 - Elsevier
NLRP3 inflammasome is a key component of the innate immune system, mediating the
activation of caspase-1, and the maturity and secretion of the pro-inflammatory cytokine …

[HTML][HTML] Effects of N-acetylcysteine on spexin immunoreactivity in kidney tissues of rats treated with adriamycin

T Yalçin, T Kuloğlu, NK Tektemur… - Iranian Journal of …, 2024 - ncbi.nlm.nih.gov
Objective (s): Due to its negative side effects, mainly nephrotoxicity, adriamycin (ADR) is
used fairly infrequently. The purpose of this study is to investigate the effects of N-acetyl …

Protective Role of Melatonin Against Abamectin-Induced Biochemical, Immunohistochemical, and Ultrastructural Alterations in the Testicular Tissues of Rats

C Adiguzel, H Karaboduk… - Microscopy and …, 2024 - academic.oup.com
Abamectin is one of the most widely used pesticides due to its strong insecticidal and
anthelmintic activities. Melatonin is a neurohormone with potent antioxidant, anti-apoptotic …

Ameliorative effects of thymoquinone on the caspase 3, kidney function and oxidative stress tartrazine-induced nephrotoxicity

Z Erdemli, M Gul, N Gokturk, E Kayhan, N Demircigil… - Toxicon, 2024 - Elsevier
First in the literature this study aimed to investigate the effects of Tartrazine, a common
industrial food dye, on kidney and whether Thymoquinone has a protective effect in …

Crocin, the compound of the dried stigma of Crocus sativus L (saffron), restores doxorubicin-induced disturbances in kidney functioning, oxidative stress, inflammation …

E Altinoz, D Cetinavci… - Natural Product …, 2024 - Taylor & Francis
Doxorubicin (Dox), an anthracycline antibiotic, is a chemotherapeutic drug for several
cancer treatments. However, its clinical usage has been restricted because of severe side …

Thymoquinone: An Effective Natural Compound for Kidney Protection

H Zhang, Y Liu, Y Dong, G Li, S Wang - The American Journal of …, 2024 - World Scientific
Kidney disease is a common health problem worldwide. Acute or chronic injuries may
interfere with kidney functions, eventually resulting in irreversible kidney damage. A number …

Evaluation of the protective effect of losartan in acetaminophen-induced liver and kidney damage in mice

S Şahin, AÇ Aydın, AY Göçmen, E Kaymak - … -Schmiedeberg's Archives of …, 2024 - Springer
Acetaminophen is widely used among humans as an antipyretic and analgesic. In this study,
the protective effect of losartan in hepatotoxicity and nephrotoxicity induced by …