Bleeding and Thrombosis: Insights into Pathophysiology of Bothrops Venom-Related Hemostasis Disorders

S Larréché, JP Chippaux, L Chevillard… - International Journal of …, 2021 - mdpi.com
Toxins from Bothrops venoms targeting hemostasis are responsible for a broad range of
clinical and biological syndromes including local and systemic bleeding, incoagulability …

Edema, hyperalgesia and myonecrosis induced by Brazilian bothropic venoms: Overview of the last decade

CCN Mamede, BB de Sousa Simamoto… - Toxicon, 2020 - Elsevier
Snakebite accidents are considered serious public health problems. They are often
neglected, and individuals who have received insufficient treatment are subjected to various …

[HTML][HTML] Bothrops atrox, the most important snake involved in human envenomings in the amazon: How venomics contributes to the knowledge of snake biology and …

WM Monteiro, JC Contreras-Bernal, PF Bisneto… - Toxicon: X, 2020 - Elsevier
Bothrops atrox snakes are mostly endemic of the Amazon rainforest and is certainly the
South American pit viper responsible for most of the snakebites in the region. The …

Molecular mechanisms underlying intraspecific variation in snake venom

DR Amazonas, JA Portes-Junior, MY Nishiyama-Jr… - Journal of …, 2018 - Elsevier
Elucidating the molecular mechanisms underlying snake venom variability provides
important clues for understanding how the biological functions of this powerful toxic arsenal …

Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms

JM Gutiérrez, A Rucavado, T Escalante, C Herrera… - Toxicon, 2018 - Elsevier
Snakebite envenoming by viperid species, and by some elapids, is characterized by a
complex pattern of tissue damage at the anatomical site of venom injection. In severe cases …

Peptide linker increased the stability of pneumococcal fusion protein vaccine candidate

L Zane, S Kraschowetz, MM Trentini… - … in Bioengineering and …, 2023 - frontiersin.org
Streptococcus pneumoniae is a bacterial pathogen exclusive to humans, responsible for
respiratory and systemic diseases. Pneumococcal protein vaccines have been proposed as …

Snake venom components in medicine: From the symbolic rod of Asclepius to tangible medical research and application

MI Estevão-Costa, R Sanz-Soler… - The international journal …, 2018 - Elsevier
Both mythologically and logically, snakes have always fascinated man. Snakes have
attracted both awe and fear not only because of the elegant movement of their limbless …

Individual Variability in Bothrops atrox Snakes Collected from Different Habitats in the Brazilian Amazon: New Findings on Venom Composition and Functionality

LF Sousa, ML Holding, THM Del-Rei, MMT Rocha… - Toxins, 2021 - mdpi.com
Differences in snake venom composition occur across all taxonomic levels and it has been
argued that this variation represents an adaptation that has evolved to facilitate the capture …

Bad things come in small packages”: predicting venom-induced coagulopathy in Bothrops atrox bites using snake ontogenetic parameters

JCC Bernal, PF Bisneto, JPT Pereira… - Clinical …, 2020 - Taylor & Francis
Introduction: Snake venom composition shows significant inter-and intra-species variation.
In the case of the viperid species Bothrops atrox, responsible for the majority of snakebites in …

[HTML][HTML] Functional variability of Bothrops atrox venoms from three distinct areas across the Brazilian Amazon and consequences for human envenomings

THM Del-Rei, LF Sousa, MMT Rocha… - Toxicon, 2019 - Elsevier
Variability in the composition of snake venoms occurs in different taxa and is usually
correlated to snake fitness. Here, we compared B. atrox venoms from three different …