The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …

Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Cilia, organelles that move to execute functions like fertilization and signal to execute
functions like photoreception and embryonic patterning, are composed of a core of nine-fold …

Farnesylation and carboxymethylation of KRAS4b (Kirsten rat sarcoma isoform 4b) are
essential for its interaction with the plasma membrane where KRAS-mediated signaling …

Phosphoinositides (PIs) are phospholipids derived from phosphatidylinositol. PIs are
regulated via reversible phosphorylation, which is directed by the opposing actions of PI …

Since its discovery as an oncogene more than 40 years ago, Ras has been and still is in the
focus of many academic and pharmaceutical labs around the world. A huge amount of work …

Primary cilia act as cell surface antennae, coordinating cellular responses to sensory inputs
and signalling molecules that regulate developmental and homeostatic pathways. Cilia are …

Joubert syndrome (JBTS) is a genetically heterogeneous autosomal-recessive
neurodevelopmental ciliopathy. We investigated further the underlying genetic etiology of …

Cilia and flagella are highly conserved organelles in eukaryotic cells that drive cell
movement and act as cell antennae that receive and transmit signals. In addition to receiving …

ABSTRACT ARL13B (a small GTPase) and INPP5E (a phosphoinositide 5-phosphatase)
are ciliary proteins encoded by causative genes of Joubert syndrome. We here showed, by …