Intrahepatic hypothyroidism in MASLD: Role of liver-specific thyromimetics including resmetirom

MS Kuchay, S Isaacs, A Misra - … & Metabolic Syndrome: Clinical Research & …, 2024 - Elsevier
Background and aims Thyroid hormones are important regulators of hepatic lipid
homeostasis and whole-body energy expenditure. Recent evidence suggests that euthyroid …

Actions of thyroid hormones and thyromimetics on the liver

RA Sinha, E Bruinstroop, PM Yen - Nature Reviews Gastroenterology & …, 2024 - nature.com
Thyroid hormones (triiodothyronine and thyroxine) are pivotal for metabolic balance in the
liver and entire body. Dysregulation of the hypothalamus–pituitary–thyroid axis can …

[PDF][PDF] Clinical Research & Reviews

MS Kuchay, S Isaacs, A Misra - Diabetes & Metabolic Syndrome …, 2024 - researchgate.net
Background and aims: Thyroid hormones are important regulators of hepatic lipid
homeostasis and whole-body energy expenditure. Recent evidence suggests that euthyroid …

Synthetic Thyroid Hormone Receptor-β Agonists Promote Oligodendrocyte Precursor Cell Differentiation in the Presence of Inflammatory Challenges

VA Baldassarro, C Quadalti, M Runfola, C Manera… - Pharmaceuticals, 2023 - mdpi.com
Oligodendrocytes and their precursors are the cells responsible for developmental
myelination and myelin repair during adulthood. Their differentiation and maturation …

[HTML][HTML] 3D culture models to study pathophysiology of steatotic liver disease

A Caddeo, S Maurotti, L Kovooru, S Romeo - Atherosclerosis, 2024 - Elsevier
Steatotic liver disease (SLD) refers to a spectrum of diseases caused by hepatic lipid
accumulation. SLD has emerged as the leading cause of chronic liver disease worldwide …

[HTML][HTML] Drug discovery targeting thyroid hormone receptor β (THRβ) for the treatment of liver diseases and other medical indications

K Wang, F Chen, J Wang, H Liu - Acta Pharmaceutica Sinica B, 2024 - Elsevier
Thyroid hormone receptors (THRs), a crucial nuclear receptor protein family, primarily
consist of two categories: α receptors and β receptors. Among them, THRβ is the primary …

代谢相关脂肪性肝病靶向药物治疗进展

宗廷妮, 戴光荣, 赵晓宇, 李瑞风, 柴聪敏 - 临床荟萃, 2023 - huicui.hebmu.edu.cn
代谢相关脂肪性肝病的患病率逐年上升, 已成为我国最常见的慢性肝脏疾病,
严重危害人类健康并对社会造成了巨大的经济负担. 目前代谢相关脂肪性肝病的一线治疗主要是 …