Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: Synthetic approaches and multifarious applications

I Khan, A Ibrar, N Abbas, A Saeed - European Journal of Medicinal …, 2014 - Elsevier
Drug development has been a principal driving force in the rapid maturation of the field of
medicinal chemistry during the past several decades. During this period, the intriguing and …

Thioethers: an overview

MI Han, ŦG Küçükgüzel - Current drug targets, 2022 - benthamdirect.com
Spreading rapidly in recent years, cancer has become one of the causes of the highest
mortality rates after cardiovascular diseases. The reason for cancer development is still not …

[HTML][HTML] Synthesis and Antimicrobial Activity of 6-Thioxo-6, 7-dihydro-2H-[1, 2, 4] triazino [2, 3-c]-quinazolin-2-one Derivatives

IS Nosulenko, OY Voskoboynik… - Scientia …, 2014 - pmc.ncbi.nlm.nih.gov
Abstract Potassium 8-R1-9-R2-10-R3-3-R-2-oxo-2H-[1, 2, 4] triazino [2, 3-c] quinazoline-6-
thiolates 2.1–2.26 were synthesized via cyclocondensation of 6-R-3-(3-R1-4-R2-5-R3 …

[HTML][HTML] Potential of N-aryl (benzyl, heteryl)-2-(tetrazolo [1, 5-c] quinazolin-5-ylthio) acetamides as anticancer and antimicrobial agents

OM Antypenko, LM Antypenko, SI Kovalenko… - Arabian Journal of …, 2016 - Elsevier
The death rate from cancer and infectious diseases is still very high, therefore research in
this area is extremely important and promising as in medical, so in economic point of view …

Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs

OY Voskoboynik, OS Kolomoets, GG Berest… - Chemistry of …, 2017 - Springer
The known methods for synthesis of thioxopyrimidines and their condensed analogs with
exocyclic sulfur atom are summarized and discussed. The most popular approaches are …

Synthesis and antiviral activity of [(9-R1-10-R2-3-R-2-оxo-2H-[1, 2, 4]-triazino [2, 3-с] quinazolin-6-yl) thio] acetamides derivatives with the fragments of carcass …

IS Nosulenko, OY Voskoboynik, GG Berest… - Журнал органічної …, 2014 - irbis-nbuv.gov.ua
Алкілування калій 9-R<^> 1-10-R<^> 2-3-R-2-оксо-2Н-[1, 2, 4] триазино [2, 3-с] хіназолін-
6-тіолатів N-циклоалкіл-(циклоалкіларил-)-2-хлорацетамідами та взаємодія …

[1,2,4]Triazino[2,3-с]quinazolines 1. Methods for the preparation and spectral characteristics of substituted 3-R1-6-R3-6,7-dihydro-2H-[1,2,4]triazino[2,3-с] …

OY Voskoboynik, OS Kolomoets, SI Kovalenko… - Chemistry of …, 2017 - Springer
A simple and effective method has been developed for the synthesis of previously unknown
substituted 3-R 1-6-R 3-6, 7-dihydro-2 H-[1, 2, 4] triazino-[2, 3-c] quinazolin-2-ones by …

[1,2,4]Triazino[2,3-с]quinazolines 3*. Structure and anticancer activity of products obtained from reaction of 3-(2-aminophenyl)-6-R-1,2,4-triazin-5(2H)-ones with aryl …

OY Voskoboynik, SV Shishkina… - Chemistry of Heterocyclic …, 2018 - Springer
Reactions of 3-(2-aminophenyl)-6-R-1, 2, 4-triazin-5 (2 H)-ones with aryl isocyanates and
aryl isothiocyanates were studied by using solvents of various nature, as well as varying the …

Benzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones electro-deficient heterocyclic compounds with promising anticancer activity

OY Voskoboynik, SI Kovalenko… - Heterocyclic …, 2016 - degruyter.com
The synthesis and antitumor activity of substituted benzo [e][1, 2, 4] triazino [2, 3-c][1, 2, 3]
triazin-2-ones–novel electro-deficient tricyclic compounds–are described. These …

Bioluminescent bacteria of the Black Sea and Sea of Azov

A Katsev, I Sazykin, L Khmelevtsova… - Marine Biological …, 2024 - marine-biology.ru
The aim of the present study was to isolate bioluminescent strains from the northern Black
Sea and Sea of Azov, analyze their morphological and biochemical characteristics, and …