During herpes simplex virus (HSV) latency, the viral genome is harbored in peripheral
neurons in the absence of infectious virus but with the potential to restart infection. Advances …

A signature trait of neurotropic α-herpesviruses (α-HV) is their ability to establish stable non-
productive infections of peripheral neurons termed latency. This specialized gene …

Herpes simplex virus 1 (HSV-1) uses latency in peripheral ganglia to persist in its human
host, however, recurrent reactivation from this reservoir can cause debilitating and …

Herpes simplex virus type-1 (HSV-1) establishes a life-long latent infection in peripheral
neurons. This latent reservoir is the source of recurrent reactivation events that ensure …

Pseudorabies virus (PRV) belongs to the alpha herpesvirus family and is responsible for
Aujeszky's disease in pigs. Similar to other alpha herpesviruses, PRV establishes a lifelong …

Latent HSV-1 genomes are chromatinized with silencing marks. Since 2004, however, there
has been an apparent inconsistency in the studies of the chromatinization of the HSV-1 …

Our current understanding of HSV latency is based on a variety of clinical observations, and
in vivo, ex vivo, and in vitro model systems, each with unique advantages and drawbacks …

Bell's Palsy is the most frequent acute neuropathy of cranial nerves; it has been associated
in various reports to herpes viruses. In a prospective study we searched the presence of …

Background Heat-induced reactivation of herpes simplex virus type 1 (HSV1) in geniculate
ganglion neurons (GGNs) is thought to cause of DFP after otologic surgery. Antiherpetic …

We describe a primary neuronal culture system suitable for molecular characterization of
herpes simplex virus type 1 (HSV-1) infection, latency, and reactivation. While several …