CD39 and CD73 in immunity and inflammation
The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration,
magnitude, and chemical nature of purinergic signals delivered to immune cells through the …
magnitude, and chemical nature of purinergic signals delivered to immune cells through the …
Adenosine and inflammation: what's new on the horizon?
Highlights•Adenosine contributes to tissue integrity by modulating the immune
system.•Adenosine receptor ligands emerged for the management of inflammation.•These …
system.•Adenosine receptor ligands emerged for the management of inflammation.•These …
Pharmacology of adenosine receptors in the vasculature
R Tabrizchi, S Bedi - Pharmacology & therapeutics, 2001 - Elsevier
Adenosine is widely distributed in mammals. One of the primary roles of adenosine within
the cardiovascular system is to directly control the functions of both cardiac and vascular …
the cardiovascular system is to directly control the functions of both cardiac and vascular …
A2A-Adenosine Receptor Reserve for Coronary Vasodilation
JC Shryock, S Snowdy, PG Baraldi, B Cacciari… - Circulation, 1998 - Am Heart Assoc
Background—Adenosine is a potent coronary vasodilator and causes an increase of
coronary blood flow by activation of A2A-adenosine receptors (A2A-AdoRs). The purpose of …
coronary blood flow by activation of A2A-adenosine receptors (A2A-AdoRs). The purpose of …
Adenosine A2A receptors mediate coronary microvascular dilation to adenosine: role of nitric oxide and ATP-sensitive potassium channels
Adenosine is a potent vasodilator that plays an important role in the regulation of coronary
microvascular diameter. Although multiple adenosine receptor subtypes have been recently …
microvascular diameter. Although multiple adenosine receptor subtypes have been recently …
Regulation of Hippocampal Postnatal and Adult Neurogenesis by Adenosine A2A Receptor: Interaction with Brain-Derived Neurotrophic Factor
FF Ribeiro, F Ferreira, RS Rodrigues, R Soares… - Stem …, 2021 - academic.oup.com
Abstract Adenosine A2A receptor (A2AR) activation modulates several brain processes,
ranging from neuronal maturation to synaptic plasticity. Most of these actions occur through …
ranging from neuronal maturation to synaptic plasticity. Most of these actions occur through …
Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: inverse relationship between affinity and duration of action of A2A agonists
Z Gao, Z Li, SP Baker, RD Lasley, S Meyer… - … of Pharmacology and …, 2001 - ASPET
Several potent and selective A2A adenosine receptor agonists are currently available.
These compounds have a high affinity for the A2A receptor and a long duration of action …
These compounds have a high affinity for the A2A receptor and a long duration of action …
Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine
JN Yang, JF Chen… - American Journal of …, 2009 - journals.physiology.org
Heart rate (HR), body temperature (Temp), locomotor activity (LA), and oxygen consumption
(O2C) were studied in awake mice lacking one or both of the adenosine A1 or A2A receptors …
(O2C) were studied in awake mice lacking one or both of the adenosine A1 or A2A receptors …
Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats
AK Dhalla, MY Wong, WQ Wang, I Biaggioni… - … of Pharmacology and …, 2006 - ASPET
Adenosine-induced tachycardia is suggested to be mediated via A2A receptors; however,
the exact mechanism for this effect remains to be understood. The present study was carried …
the exact mechanism for this effect remains to be understood. The present study was carried …
Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels
A Leiva, E Guzman-Gutierrez… - Molecular Aspects of …, 2017 - Elsevier
Adenosine as well as agonists and antagonists for the four adenosine receptor subtypes
(A1R, A2AR, A2BR and A3R) play a role in several key physiological and …
(A1R, A2AR, A2BR and A3R) play a role in several key physiological and …