Gene drives gaining speed
E Bier - Nature Reviews Genetics, 2022 - nature.com
Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …
Genome-editing technologies for gene and cell therapy
ML Maeder, CA Gersbach - Molecular therapy, 2016 - cell.com
Gene therapy has historically been defined as the addition of new genes to human cells.
However, the recent advent of genome-editing technologies has enabled a new paradigm in …
However, the recent advent of genome-editing technologies has enabled a new paradigm in …
Reprogramming the tumor microenvironment by genome editing for precision cancer therapy
K Liu, JJ Cui, Y Zhan, QY Ouyang, QS Lu, DH Yang… - Molecular Cancer, 2022 - Springer
The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays
essential roles in tumor development and metastasis. The clinical outcomes of tumors are …
essential roles in tumor development and metastasis. The clinical outcomes of tumors are …
Prokaryotic Virus Orthologous Groups (pVOGs): a resource for comparative genomics and protein family annotation
AL Grazziotin, EV Koonin… - Nucleic acids research, 2016 - academic.oup.com
Viruses are the most abundant and diverse biological entities on earth, and while most of
this diversity remains completely unexplored, advances in genome sequencing have …
this diversity remains completely unexplored, advances in genome sequencing have …
Biodiversity of bacteriophages: morphological and biological properties of a large group of phages isolated from urban sewage
A Jurczak-Kurek, T Gąsior, B Nejman-Faleńczyk… - Scientific reports, 2016 - nature.com
A large scale analysis presented in this article focuses on biological and physiological
variety of bacteriophages. A collection of 83 bacteriophages, isolated from urban sewage …
variety of bacteriophages. A collection of 83 bacteriophages, isolated from urban sewage …
Targeted DNA insertion in plants
Conventional methods of DNA sequence insertion into plants, using Agrobacterium-
mediated transformation or microprojectile bombardment, result in the integration of the DNA …
mediated transformation or microprojectile bombardment, result in the integration of the DNA …
Advances in mammalian cell line development technologies for recombinant protein production
T Lai, Y Yang, SK Ng - Pharmaceuticals, 2013 - mdpi.com
From 2006 to 2011, an average of 15 novel recombinant protein therapeutics have been
approved by US Food and Drug Administration (FDA) annually. In addition, the expiration of …
approved by US Food and Drug Administration (FDA) annually. In addition, the expiration of …
Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy
G Silva, L Poirot, R Galetto, J Smith… - Current gene …, 2011 - ingentaconnect.com
The importance of safer approaches for gene therapy has been underscored by a series of
severe adverse events (SAEs) observed in patients involved in clinical trials for Severe …
severe adverse events (SAEs) observed in patients involved in clinical trials for Severe …
Site-specific selfish genes as tools for the control and genetic engineering of natural populations
A Burt - Proceedings of the Royal Society of London …, 2003 - royalsocietypublishing.org
Site-specific selfish genes exploit host functions to copy themselves into a defined target
DNA sequence, and include homing endonuclease genes, group II introns and some LINE …
DNA sequence, and include homing endonuclease genes, group II introns and some LINE …