Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …

Cu (I)-catalyzed azide–alkyne 1, 3-dipolar cycloaddition (CuAAC), popularly known as the
“click reaction”, serves as the most potent and highly dependable tool for facile construction …

Chemical modification of nucleic acids in living cells can be sterically hindered by tight
packing of bioorthogonal functional groups in chromatin. To address this limitation, we report …

Conspectus Protein biosynthesis is a central process in all living cells that is catalyzed by a
complex molecular machine─ the ribosome. This process is termed translation because the …

The fluorescent intensity of Cy3 and Cy5 dyes is strongly dependent on the nucleobase
sequence of the labeled oligonucleotides. Sequence-dependent fluorescence may …

Cellular RNA labeling strategies based on bioorthogonal chemical reactions are much less
developed in comparison to glycan, protein and DNA due to its inherent instability and lack …

The development of facile methods for conjugating relevant probes, ligands, or delivery
agents onto oligonucleotides (ONs) is highly desirable both for fundamental studies in …

Real‐time tracking of RNA expression can provide insight into the mechanisms used to
generate cellular diversity, as well as help determine the underlying causes of disease. Here …

Inverse electron demand Diels–Alder cycloadditions are extremely useful tools for
orthogonal labeling of biomolecules such as proteins or small molecules in a cellular …

Pd-catalyzed CC bond formation, an important vertebra in the spine of synthetic chemistry, is
emerging as a valuable chemoselective transformation for post-synthetic functionalization of …