The bone marrow as sanctuary for plasma cells and memory T-cells: implications for adaptive immunity and vaccinology

SA Slamanig, MA Nolte - Cells, 2021 - mdpi.com
The bone marrow (BM) is key to protective immunological memory because it harbors a
major fraction of the body's plasma cells, memory CD4+ and memory CD8+ T-cells. Despite …

[HTML][HTML] Blasts in context: the impact of the immune environment on acute myeloid leukemia prognosis and treatment

Y Serroukh, J Hébert, L Busque, F Mercier, CE Rudd… - Blood Reviews, 2023 - Elsevier
Acute myeloid leukemia (AML) is a cancer that originates from the bone marrow (BM). Under
physiological conditions, the bone marrow supports the homeostasis of immune cells and …

[HTML][HTML] In vivo imaging of CD8+ T cells in metastatic cancer patients: first clinical experience with simultaneous [89Zr] Zr-Df-IAB22M2C PET/MRI

J Schwenck, D Sonanini, D Seyfried, W Ehrlichmann… - Theranostics, 2023 - ncbi.nlm.nih.gov
Aim/Introduction: Despite the spectacular success of immune checkpoint inhibitor therapy
(ICT) in patients with metastatic cancer, only a limited proportion of patients benefit from ICT …

Interactions of B-lymphocytes and bone cells in health and disease

D Grčević, A Sanjay, J Lorenzo - Bone, 2023 - Elsevier
Bone remodeling occurs through the interactions of three major cell lineages, osteoblasts,
which mediate bone formation, osteocytes, which derive from osteoblasts, sense mechanical …

Prevention effect of protopanaxadiol-type saponins saponins and protopanaxatriol-type saponins on myelosuppression mice induced by cyclophosphamide

H Zhang, L Zhang, C Yang, Y Zhang, J Li… - Frontiers in …, 2022 - frontiersin.org
Ginsenosides from ginseng are used as a therapeutic agent for various diseases. They
enhance the immunomodulatory effect in cyclophosphamide (CP)-treated tumor disease …

IL-9 secreted by leukemia stem cells induces Th1-skewed CD4+ T cells, which promote their expansion

R Radpour, C Simillion, B Wang, HA Abbas, C Riether… - Blood, 2024 - ashpublications.org
In acute myeloid leukemia (AML), leukemia stem cells (LSCs) and leukemia progenitor cells
(LPCs) interact with various cell types in the bone marrow (BM) microenvironment …

B cell/stromal cell crosstalk in health, disease, and treatment: Follicular lymphoma as a paradigm

C Lamaison, K Tarte - Immunological Reviews, 2021 - Wiley Online Library
Stromal cells organize specific anatomic compartments within bone marrow (BM) and
secondary lymphoid organs where they finely regulate the behavior of mature normal B …

Three-dimensional human bone marrow organoids for the study and application of normal and abnormal hematoimmunopoiesis

A de Janon, A Mantalaris… - The Journal of …, 2023 - journals.aai.org
Hematoimmunopoiesis takes place in the adult human bone marrow (BM), which is
composed of heterogeneous niches with complex architecture that enables tight regulation …

The dynamics of B‐cell reconstitution post allogeneic hematopoietic stem cell transplantation: A real‐world study

G Zhou, Q Zhan, L Huang, X Dou, J Cui… - Journal of Internal …, 2024 - Wiley Online Library
Background The immune reconstitution after allogeneic hematopoietic stem cell
transplantation (allo‐HSCT) is crucial for preventing infections and relapse and enhancing …

Clinical characteristics of antithyroid drug-induced aplastic anemia cases over the past 30 years

Y Cheng, XY Xia, W Zhang, L Ren, CF Tian… - Frontiers in …, 2023 - frontiersin.org
Objective The authors aimed to investigate the clinical characteristics of antithyroid drug-
induced aplastic anemia cases over the past 30 years. Methods The data of patients with …