Schizophrenia is frequently a chronic and disabling disorder, characterized by
heterogeneous positive and negative symptom constellations. The objective of this review …

Apathy and anhedonia are common syndromes of motivation that are associated with a wide
range of brain disorders and have no established therapies. Research using animal models …

BackgroundDuring the last decades, a renewed interest for negative symptoms (NS) was
brought about by the increased awareness that they interfere severely with real-life …

Objective To provide a comprehensive analysis of cytokine perturbations in antipsychotic‐
naïve first‐episode psychosis (FEP) populations and assess the relationship between …

Negative symptoms have long been conceptualized as a core aspect of schizophrenia. They
play a key role in the functional outcome of the disorder, and their management represents a …

Background Two objectives of the NIMH Research Domain Criteria (RDoC) initiative are to
identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) …

Anhedonia, or markedly diminished interest or pleasure, is a hallmark symptom of major
depression, schizophrenia and other neuropsychiatric disorders. Over the past three …

In people suffering from schizophrenia, major areas of everyday life are impaired, including
independent living, productive activities and social relationships. Enhanced understanding …

Objective A major barrier to developing treatments for negative symptoms has been
measurement concerns with existing assessment tools. Fulfilling the top recommendation of …

Research on negative symptoms of schizophrenia has received renewed interest since the
1980s. A scientometric analysis that objectively maps scientific knowledge, with changes in …