[HTML][HTML] Fateful Decisions of Where to Cut the Line: Pathology Associated with Aberrant 3′ End Processing and Transcription Termination
P Grzechnik, HE Mischo - Journal of molecular biology, 2025 - Elsevier
Aberrant gene expression lies at the heart of many pathologies. This review will point out
how 3′ end processing, the final mRNA-maturation step in the transcription cycle, is …
how 3′ end processing, the final mRNA-maturation step in the transcription cycle, is …
HSV-1 infection induces a downstream shift of promoter-proximal pausing for host genes
E Weiß, T Hennig, P Graßl, L Djakovic… - Journal of …, 2023 - Am Soc Microbiol
ABSTRACT Herpes simplex virus 1 (HSV-1) infection exerts a profound shutoff of host gene
expression at multiple levels. Recently, HSV-1 infection was reported to also impact …
expression at multiple levels. Recently, HSV-1 infection was reported to also impact …
A Revision of Herpes Simplex Virus Type 1 Transcription: First, Repress; Then, Express
LEM Dunn, CH Birkenheuer, JD Baines - Microorganisms, 2024 - mdpi.com
The herpes virus genome bears more than 80 strong transcriptional promoters. Upon entry
into the host cell nucleus, these genes are transcribed in an orderly manner, producing five …
into the host cell nucleus, these genes are transcribed in an orderly manner, producing five …
Impact of the interaction between herpes simplex virus 1 ICP22 and FACT on viral gene expression and pathogenesis
S Liu, Y Maruzuru, K Takeshima, N Koyanagi… - Journal of …, 2024 - journals.asm.org
Facilitates chromatin transcription (FACT) interacts with nucleosomes to promote gene
transcription by regulating the dissociation and reassembly of nucleosomes downstream …
transcription by regulating the dissociation and reassembly of nucleosomes downstream …
[HTML][HTML] ICP22-defined condensates mediate RNAPII deubiquitylation by UL36 and promote HSV-1 transcription
H Qi, M Yin, F Xiong, X Ren, K Chen, H Qin, E Wang… - Cell Reports, 2024 - cell.com
Herpes simplex virus type I (HSV-1) infection leads to RNA polymerase II (RNAPII)
degradation and host transcription shutdown. We show that ICP22 defines the virus-induced …
degradation and host transcription shutdown. We show that ICP22 defines the virus-induced …
White spot syndrome virus IE1 protein blocks the integrin-FAK signaling to enhance viral infection in shrimp
K Lu, X Chen, H Zhang, J Zhu, Y Zhao, X Chen… - Fish & Shellfish …, 2025 - Elsevier
DNA viruses commonly utilize immediate-early proteins to manipulate cellular signaling
pathways in order to facilitate their infection. Our previous research has suggested that IE1 …
pathways in order to facilitate their infection. Our previous research has suggested that IE1 …
HSV-1 infection induces a downstream-shift of the+ 1 nucleosome
Abstract Herpes simplex virus 1 (HSV-1) infection induces a genome-wide loss of host
transcriptional activity and widespread disruption of host transcription termination. The latter …
transcriptional activity and widespread disruption of host transcription termination. The latter …
HSV-1 infection induces a downstream shift of promoter-proximal pausing linked to H2A. Z-containing+ 1 nucleosomes
E Weiß, T Hennig, P Graßl, L Djakovic, AW Whisnant… - bioRxiv, 2022 - biorxiv.org
Abstract Herpes simplex virus 1 (HSV-1) infection exerts a profound shut-off of host gene
expression at multiple levels. Recently, HSV-1 infection was reported to also impact …
expression at multiple levels. Recently, HSV-1 infection was reported to also impact …