Molecular pathways of major depressive disorder converge on the synapse

GR Fries, VA Saldana, J Finnstein, T Rein - Molecular Psychiatry, 2023 - nature.com
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Tryptophan metabolism in depression: a narrative review with a focus on serotonin and kynurenine pathways

AS Correia, N Vale - International journal of molecular sciences, 2022 - mdpi.com
Depression is a common and serious disorder, characterized by symptoms like anhedonia,
lack of energy, sad mood, low appetite, and sleep disturbances. This disease is very …

The misestimation of uncertainty in affective disorders

E Pulcu, M Browning - Trends in cognitive sciences, 2019 - cell.com
Our knowledge about the state of the world is often incomplete, making it difficult to select
the best course of action. One strategy that can be used to improve our ability to make …

GLP-1a: going beyond traditional use

LF Laurindo, SM Barbalho, EL Guiguer… - International Journal of …, 2022 - mdpi.com
Glucagon-like peptide-1 (GLP-1) is a human incretin hormone derived from the proglucagon
molecule. GLP-1 receptor agonists are frequently used to treat type 2 diabetes mellitus and …

Hippocampal and amygdalar volume changes in major depressive disorder: a targeted review and focus on stress

M Nolan, E Roman, A Nasa, KJ Levins… - Chronic …, 2020 - journals.sagepub.com
Medial temporal lobe structures have long been implicated in the pathogenesis of major
depressive disorder. Although findings of smaller hippocampal and amygdalar volumes are …

Depression and cognitive impairment—extrahepatic manifestations of NAFLD and NASH

M Colognesi, D Gabbia, S De Martin - Biomedicines, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) and its complication non-alcoholic steatohepatitis
(NASH) are important causes of liver disease worldwide. Recently, a significant association …

Cerebral chemoarchitecture shares organizational traits with brain structure and function

B Hänisch, JY Hansen, BC Bernhardt, SB Eickhoff… - ELife, 2023 - elifesciences.org
Chemoarchitecture, the heterogeneous distribution of neurotransmitter transporter and
receptor molecules, is a relevant component of structure–function relationships in the human …

Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from migraine: a case–control study

R Magdy, A Elmazny, SH Soliman, EH Elsebaie… - The Journal of …, 2022 - Springer
Background The burden of post-coronavirus disease (COVID)-19 symptoms has been
increasing and is of great concern in patients with pre-existing chronic medical conditions …

Classical psychedelics as therapeutics in psychiatry–current clinical evidence and potential therapeutic mechanisms in substance use and mood disorders

LJ Mertens, KH Preller - Pharmacopsychiatry, 2021 - thieme-connect.com
Classical psychedelics, primarily psilocybin and lysergic acid diethylamide (LSD), have
been used and extensively studied in Western medicine as part of substance-assisted …

Potential role of curcumin for the treatment of major depressive disorder

AL Lopresti - CNS drugs, 2022 - Springer
Curcumin is the major biologically active polyphenolic constituent in the turmeric plant
(Curcuma longa) that has been shown to have antioxidant, anti-inflammatory …