Cardiovascular disease (CVD), which includes cardiomyopathy/heart failure, coronary artery
disease, stroke, pericardial disease, arrhythmias, and valvular and vascular dysfunction, is a …

It is now increasingly appreciated that inflammation is not limited to the control of pathogens
by the host, but rather that sterile inflammation which occurs in the absence of viral or …

Anthracyclines is an effective chemotherapeutic treatment used for many types of cancer.
However, high cumulative dosage of anthracyclines leads to cardiac toxicity and heart …

Cancer patients receiving anthracycline-based chemotherapy are at risk to develop life-
threatening chronic cardiotoxicity with the pathophysiological mechanism of action not fully …

Background Recent studies have shown an association between statin therapy and a
reduced risk of heart failure among breast cancer survivors. Our goal was to evaluate …

Purpose Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
inflammasome is important in inflammation of several diabetic complications. However, the …

Key points Endothelial inwardly rectifying K+ (Kir2. 1) channels regulate flow‐induced
vasodilatation via nitric oxide (NO) in mouse mesenteric resistance arteries. Deficiency of …

Cardiac injury is the main dose-limiting factor for doxorubicin (Dox) use as an anticancer
agent. The cardiotoxicity of Dox is linked to a number of complex mechanisms, including …

Grape seed proanthocyanidins (GSPE) and ginkgo biloba extract (EGb761) are considered
to have protective effects against several diseases. The cardiotoxicity of doxorubicin (DOX) …

Statins are widely used drugs for their role in decreasing cholesterol in
hypercholesterolemic patients. Statins through inhibition of Hydroxy Methyl Glutaryl-CoA …