Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence
indicates that the mitral valve is not a passive structure, but—even in adult life—remains …

Over the past two decades interest in mitral valve regurgitation has increased as a result of
the development of new technologies that have expanded the number of patients who can …

Aims Significant efforts are currently undertaken to reduce functional mitral regurgitation
(FMR) in patients with chronic heart failure in the hope to improve prognosis. We aimed to …

Background Functional mitral regurgitation (FMR) is a common finding in patients with heart
failure (HF), but its effect on outcome is still uncertain, mainly because in previous studies …

Aims To examine the independent prognostic role of functional mitral regurgitation (FMR)
and its impact across the severity of chronic heart failure (CHF) in a large population of …

Secondary mitral regurgitation (SMR) occurs as a result of multifactorial left atrioventricular
dysfunction and maleficent remodelling. It is the most common and undertreated form of …

The appropriateness and timing of mitral valve surgery in patients with advanced heart
failure and severe mitral regurgitation remains controversial. Recent surgical results provide …

Background Left atrial (LA) size is a marker of disease severity and is related to worse
outcomes in secondary mitral regurgitation (MR). The prognostic value of LA function …

Many cell-based therapies are challenged by the poor localization of introduced cells and
the use of biomaterial scaffolds with questionable biocompatibility or bio-functionality …

Background—Ischemic mitral regurgitation (MR) is classically ascribed to functional
restriction of normal leaflets, but recent studies have suggested post–myocardial infarction …