A growing body of evidence links type-2 diabetes (T2D) with dementia and
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …

Central nervous system (CNS) disorders and diseases are expected to rise sharply in the
coming years, partly because of the world's aging population. Medicines for the treatment of …

Epilepsy is thought to be associated with oxidative stress, glutamate excitotoxicity, and
mitochondrial dysfunction. The enhanced synthesis and release of oxygen free radicals is …

Neurodegeneration is a condition of the central nervous system (CNS) characterized by loss
of neural structures and function. The most common neurodegenerative disorders (NDDs) …

Alzheimer's disease (AD) is a multifactorial neurodegenerative condition associated with
pathological accumulation of amyloid plaques and with the appearance of deposit of …

Panax notoginseng saponins (PNS), also called “sanqi” in Chinese, are the main active
ingredients which are extracted from the root of Panax notoginseng (Burk.) FH Chen., and …

Triazole scaffolds, a series of 5-membered heterocycles, are well known for their high
efficacy, low toxicity, and superior pharmacokinetics. Alzheimer's disease (AD) is the first …

The small, calcium-sensor protein, calmodulin, is ubiquitously expressed and central to cell
function in all cell types. Here the literature linking calmodulin to Alzheimer's disease is …

N-Methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors that mediate
excitatory synaptic transmission and have been implicated in numerous neurological …

The endogenous amino acids serine and aspartate occur at high concentrations in free D-
form in mammalian organs, including the central nervous system and endocrine glands. D …