Cytokines play crucial roles in orchestrating complex multicellular interactions between
pancreatic β cells and immune cells in the development of type 1 diabetes (T1D) and are …

Background Type 1 diabetes mellitus (T1DM) is an autoimmune disorder characterized by T
cell-mediated self-destruction of insulin-secreting islet β cells. Management of T1DM is …

Inflammasome-driven release of interleukin (IL)-1β is a central element of many forms of
sterile inflammation and has been evident to promote the onset and progression of diabetic …

Type 1 diabetes mellitus (T1D) is an autoimmune disease often diagnosed in childhood that
results in pancreatic β-cell destruction and life-long insulin dependence. T1D susceptibility …

The liver is a critical organ in controlling immune tolerance. In particular, it is now clear that
targeting antigens for presentation by antigen presenting cells in the liver can induce …

It was hypothesized that IL‐1 antagonism would preserve β‐cell function in new onset Type
1 diabetes (T1D). However, the Anti‐Interleukin‐1 in Diabetes Action (AIDA) and TrialNet …

Immunotherapy for type 1 diabetes (T1D) has previously focused on suppressing the
autoimmune response against pancreatic beta cells to preserve endogenous insulin …

Diabetes is an endocrinological disorder with a rapidly increasing number of patients
globally. Over the last few years, the alarming status of diabetes has become a pivotal factor …

A self-tolerant immune system may be regained using ASIT where T effector cells are
repressed and/or T regulatory cells are induced. Administration of exogenous antigens has …

Background The non‐obese diabetic (NOD) mouse is a commonly used animal model for
studying type 1 diabetes (T1D). The aims of our study were to explore the diabetes …