Protein-based condensation mechanisms drive the assembly of RNA-rich P granules

H Schmidt, A Putnam, D Rasoloson, G Seydoux - Elife, 2021 - elifesciences.org
Germ granules are protein-RNA condensates that segregate with the embryonic germline. In
Caenorhabditis elegans embryos, germ (P) granule assembly requires MEG-3, an …

Mutator Foci Are Regulated by Developmental Stage, RNA, and the Germline Cell Cycle in Caenorhabditis elegans

CJ Uebel, D Agbede, DC Wallis… - G3: Genes, Genomes …, 2020 - academic.oup.com
RNA interference is a crucial gene regulatory mechanism in Caenorhabditis elegans. Phase-
separated perinuclear germline compartments called Mutator foci are a key element of …

Tag with Caution-How protein tagging influences the formation of condensates

KD/" orner, M Gut, D Overwijn, F Cao, M Siketanc… - bioRxiv, 2024 - biorxiv.org
Fluorescent proteins and peptide tags are essential tools in cellular biology, but can alter the
biochemical properties of target proteins. Biomolecular condensates, which have emerged …

[HTML][HTML] SIMR foci are found in the progenitor germ cells of C. elegans embryos

CJ Uebel, KI Manage, CM Phillips - microPublication biology, 2021 - ncbi.nlm.nih.gov
RNA interference is a widely conserved mechanism of gene regulation and silencing across
eukaryotes. In C. elegans, RNA silencing is coordinated through perinuclear nuage …