Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review
S Tahlan, S Kumar, B Narasimhan - BMC chemistry, 2019 - Springer
Heterocyclic compounds are inevitable in a numerous part of life sciences. These molecules
perform various noteworthy functions in nature, medication and innovation. Nitrogen …
perform various noteworthy functions in nature, medication and innovation. Nitrogen …
Therapeutic evolution of benzimidazole derivatives in the last quinquennial period
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
Recent advances of imidazole-containing derivatives as anti-tubercular agents
YL Fan, XH Jin, ZP Huang, HF Yu, ZG Zeng… - European journal of …, 2018 - Elsevier
Tuberculosis still remains one of the most common, communicable, and leading deadliest
diseases known to mankind throughout the world. Drug-resistance in Mycobacterium …
diseases known to mankind throughout the world. Drug-resistance in Mycobacterium …
Recent development of benzimidazole‐containing antibacterial agents
D Song, S Ma - ChemMedChem, 2016 - Wiley Online Library
Clinically significant antibiotic resistance is one of the greatest challenges of the twenty‐first
century. However, new antibacterial agents are currently being developed at a much slower …
century. However, new antibacterial agents are currently being developed at a much slower …
FtsZ inhibitors as a new genera of antibacterial agents
S Tripathy, SK Sahu - Bioorganic chemistry, 2019 - Elsevier
The continuous emergence and rapid spread of a multidrug-resistant strain of bacterial
pathogens have demanded the discovery and development of new antibacterial agents. A …
pathogens have demanded the discovery and development of new antibacterial agents. A …
Drug resistance mechanisms and novel drug targets for tuberculosis therapy
Drug-resistant tuberculosis (TB) poses a significant challenge to the successful treatment
and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of …
and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of …
Targeting the bacterial division protein FtsZ
KA Hurley, TMA Santos, GM Nepomuceno… - Journal of medicinal …, 2016 - ACS Publications
Similar to its eukaryotic counterpart, the prokaryotic cytoskeleton is essential for the
structural and mechanical properties of bacterial cells. The essential protein FtsZ is a central …
structural and mechanical properties of bacterial cells. The essential protein FtsZ is a central …
FtsZ as an antibacterial target: status and guidelines for progressing this avenue
The disturbing increase in the number of bacterial pathogens that are resistant to multiple, or
sometimes all, current antibiotics highlights the desperate need to pursue the discovery and …
sometimes all, current antibiotics highlights the desperate need to pursue the discovery and …
Screening of plant-based natural compounds as an inhibitor of FtsZ from Salmonella Typhi using the computational, biochemical and in vitro cell-based studies
Salmonella Typhi is emerging as a drug-resistant pathogen, particularly in developing
countries. Hence, the progressive development of new antibiotics against novel drug targets …
countries. Hence, the progressive development of new antibiotics against novel drug targets …
A Review of Approaches to the Metallic and Non-Metallic Synthesis of Benzimidazole (BnZ) and Their Derivatives for Biological Efficacy
M Patel, G Avashthi, A Gacem, MS Alqahtani, HK Park… - Molecules, 2023 - mdpi.com
Heterocyclic compounds are significant lead drug candidates based on their various
structure–activity relationships (SAR), and their use in pharmaceutics is constantly …
structure–activity relationships (SAR), and their use in pharmaceutics is constantly …