Adenovirus vectors are the most commonly employed vector for cancer gene therapy. They
are also used for gene therapy and as vaccines to express foreign antigens. Adenovirus …

Ki67 is a well-known proliferation marker for the evaluation of cell proliferation. Numerous
studies have indicated that Ki67 index independently predicts cancer progression …

Nanotechnology refers to the interactions of cellular and molecular components and
engineered materials—typically, clusters of atoms, molecules, and molecular fragments into …

Purpose: To conduct a phase I clinical trial with a second-generation oncolytic herpes
simplex virus (HSV) expressing granulocyte macrophage colony-stimulating factor (Onco …

Background JX-594 is a targeted oncolytic poxvirus designed to selectively replicate in and
destroy cancer cells with cell-cycle abnormalities and epidermal growth factor receptor …

Gynecological cancers are known for being very aggressive at their advanced stages.
Indeed, the survival rate of both ovarian and endometrial cancers is very low when …

Leveraging the immune system to thwart cancer is not a novel strategy and has been
explored via cancer vaccines and use of immunomodulators like interferons. However, it …

Viruses have been engineered for cancer therapy in a variety of ways. Approaches include
non-replicating gene therapy vectors, cancer vaccines and oncolytic viruses, but the clinical …

ONYX-015 is an oncolytic virus untested as a treatment for malignant glioma. The NABTT
CNS Consortium conducted a dose-escalation trial of intracerebral injections of ONYX-015 …

Therapeutic oncolytic viruses (virotherapeutics) constitute a novel class of targeted
anticancer agents that have unique mechanisms of action compared with other cancer …