The latest in animal models of pulmonary hypertension and right ventricular failure
Pulmonary hypertension (PH) describes heterogeneous population of patients with a mean
pulmonary arterial pressure> 20 mm Hg. Rarely, PH presents as a primary disorder but is …
pulmonary arterial pressure> 20 mm Hg. Rarely, PH presents as a primary disorder but is …
Cellular and molecular basis of pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is caused by functional and structural changes in the
pulmonary vasculature, leading to increased pulmonary vascular resistance. The process of …
pulmonary vasculature, leading to increased pulmonary vascular resistance. The process of …
Cellular and molecular pathobiology of pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) has a multifactorial pathobiology. Vasoconstriction,
remodeling of the pulmonary vessel wall, and thrombosis contribute to increased pulmonary …
remodeling of the pulmonary vessel wall, and thrombosis contribute to increased pulmonary …
Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms
KR Stenmark, KA Fagan, MG Frid - Circulation research, 2006 - Am Heart Assoc
Chronic hypoxic exposure induces changes in the structure of pulmonary arteries, as well as
in the biochemical and functional phenotypes of each of the vascular cell types, from the …
in the biochemical and functional phenotypes of each of the vascular cell types, from the …
Inflammation, growth factors, and pulmonary vascular remodeling
PM Hassoun, L Mouthon, JA Barberà… - Journal of the american …, 2009 - jacc.org
Inflammatory processes are prominent in various types of human and experimental
pulmonary hypertension (PH) and are increasingly recognized as major pathogenic …
pulmonary hypertension (PH) and are increasingly recognized as major pathogenic …
Molecular pathogenesis of pulmonary arterial hypertension
M Rabinovitch - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
Recent clinical and experimental studies are redefining the cellular and molecular bases of
pulmonary arterial hypertension (PAH). The genetic abnormalities first identified in …
pulmonary arterial hypertension (PAH). The genetic abnormalities first identified in …
Molecular pathogenesis of pulmonary arterial hypertension
M Rabinovitch - The Journal of clinical investigation, 2008 - Am Soc Clin Investig
Recent investigations have suggested that it might be possible to reverse the pathology of
pulmonary arterial hypertension (PAH), a disorder that can be rapidly progressive and fatal …
pulmonary arterial hypertension (PAH), a disorder that can be rapidly progressive and fatal …
A comprehensive review: the evolution of animal models in pulmonary hypertension research; are we there yet?
Pulmonary hypertension (PH) is a disorder that develops as a result of remodeling of the
pulmonary vasculature and is characterized by narrowing/obliteration of small pulmonary …
pulmonary vasculature and is characterized by narrowing/obliteration of small pulmonary …
Pathogenic mechanisms of pulmonary arterial hypertension
SY Chan, J Loscalzo - Journal of molecular and cellular cardiology, 2008 - Elsevier
Pulmonary arterial hypertension (PAH) is a complex disease that causes significant
morbidity and mortality and is clinically characterized by an increase in pulmonary vascular …
morbidity and mortality and is clinically characterized by an increase in pulmonary vascular …
Translating research into improved patient care in pulmonary arterial hypertension
S Bonnet, S Provencher, C Guignabert… - American journal of …, 2017 - atsjournals.org
We have witnessed significant advances in the management of pulmonary arterial
hypertension (PAH)(1), a rare and severe condition characterized by intense pulmonary …
hypertension (PAH)(1), a rare and severe condition characterized by intense pulmonary …